Mpro

"Koma zuwa Pipeline

Mpro Mai hanawa STI-1558

Yin niyya ga babban ƙwayar cuta (Mpro): katse kwafin ƙwayoyin cuta

Jeong, GU, et al. (2020). "Dabarun warkewa game da COVID-19 da Halayen Tsarin SARS-CoV-2: Bita." Iyaka a Microbiology 11(1723).

An tsara STI-1558 tare da kaddarorin masu zuwa:

  • STI-1558 prodrug ne, kuma tsarin sa AC1115 yana ɗaure zuwa Cys-145 na yankin catalytic na M.pro , wanda aka kiyaye 100% a cikin duk bambance-bambancen SARS-CoV-2 kuma ya sami babban aikin anti-SARS-CoV-2, gami da na asali na SARS-CoV-2 da kuma manyan bambance-bambancen damuwa (VOCs) , kamar Delta da Omicron.
  • STI-1558 da Hakanan mai hana Cathepsin L, wanda zai iya toshe ingantaccen shigarwar hoto ko bidiyo mai zagaya yanar gizo da sauri cikin sel masu masauki ba tare da hanzarta maye gurbi ba.
  • Rashin lafiyar baki har zuwa 76% tare da ɗaukar sauri da haɓaka bayyanar magunguna a cikin plasma da ke ba da izinin fara magani na COVID a gida ta hanyar sarrafa baki.
  • Yana guje wa amfani da mai hanawa CYP34A mai ƙarfi (misali, ritonavir) azaman mai haɓakawa don haɓaka bayyanar plasma. ba da izinin jiyya na tsaye tare da ƙananan haɗari don hulɗar miyagun ƙwayoyi.
  • A samfurin magani tare da ƙaƙƙarfan ƙira, kwanciyar hankali da manyan abubuwan kera magunguna tare da sarrafa farashi bada damar samun dama ga duniya da aikace-aikace.