ACEA Therapeutics

ACEA Therapeutics, e San Diego, California ke setsi se nang le thepa ka botlalo sa Sorrento. ACEA Therapeutics e ikemiselitse ho nts'etsapele le ho fana ka liphekolo tse ncha ho ntlafatsa maphelo a bakuli ba nang le mafu a sokelang bophelo.

Motsoako oa rona o etellang pele, Abivertinib, e leng molek'hule kinase inhibitor e nyane, hajoale e ntse e hlahlojoa ke Tsamaiso ea Lijo le Lithethefatsi ea China (CFDA) bakeng sa kalafo ea bakuli ba nang le mofetše o sa nyane oa lisele tsa matšoafo (NSCLC) o nang le phetoho ea EGFR T790M. E boetse e le litekong tsa bongaka ho phekola bakuli ba sepetlele ba nang le Covid-19 naheng ea Brazil le US e etelletsoeng pele ke Sorrento Therapeutics. Molek'hule ea bobeli e nyane ea kinase inhibitor ea ACEA, AC0058, e kenetse nts'etsopele ea Phase 1B US bakeng sa kalafo ea systemic lupus erythematosus (SLE).

Haufi le mokhatlo o matla oa R&D, ACEA e thehile bokhoni ba tlhahiso ea lithethefatsi le khoebo naheng ea China ho ts'ehetsa kholo ea rona ea nako e telele. Meralo ena ea motheo e re fa taolo e kholo holim'a ketane ea rona ea phepelo ho etsa bonnete ba hore lihlahisoa li tlisoa ho bakuli ka nako.

SILEXE

SCILEX HOLDING COMPANY ("Scilex"), e leng setsi se nang le boholo ba batho ba bangata ba Sorrento, se inehetse ho nts'etsopele le khoebo ea lihlahisoa tsa ho laola bohloko. Sehlahisoa se etelletseng pele sa k'hamphani ea ZTlido^® (lidocaine topical system 1.8%), ke sehlahisoa sa lidocaine sa topical se amohetsoeng ke US Food and Drug Administration bakeng sa ho imolla bohloko bo amanang le Post-Herpetic Neuralgia (PHN), e leng mofuta oa bohloko ba methapo ea morao-rao.

Scilex's SP-102 (10 mg dexamethasone sodium phosphate gel), kapa SEMDEXA™, bakeng sa phekolo ea Lumbar Radicular Pain e mothating oa ho phethela teko ea meriana ea Phase III. Khamphani e lebelletse hore SP-102 e tla ba ente ea pele ea FDA e lumelletsoeng e seng ea opioid epidural ho phekola bohloko ba lumbosacral radicular, kapa sciatica, e nang le monyetla oa ho nkela liente tse limilione tse 10 ho isa ho tse 11 tsa off-label epidural steroid selemo le selemo US.

Bioserv

Bioserv, e San Diego, California, ke setsi se nang le thepa ka botlalo sa Sorrento. E thehiloe ka 1988, mokhatlo ke mofani oa litšebeletso tse ka sehloohong tsa tlhahiso ea konteraka ea cGMP e nang le lisebelisoa tse fetang 35,000 tsa lisekoere-maoto tseo bokhoni ba tsona ba mantlha bo leng setsi sa tlhahiso ea bongata ba aseptic le non-aseptic; tlhoekiso; ho tlatsa; ho emisa; litšebeletso tsa lyophilization; ho ngola; kopano ea thepa e felileng; kitting le ho paka; hammoho le lits'ebeletso tse laoloang tsa polokelo ea mocheso le kabo ho ts'ehetsa lihlahisoa tsa lithethefatsi tsa Pre-Clinical, Phase I le II Clinical Trial, li-reagents tsa lisebelisoa tsa bongaka, li-reagents tsa tlhahlobo ea bongaka le lisebelisoa, le li-reagents tsa mahlale a bophelo.

Concortis-Levena

Ka 2008, Concortis Biosystems e thehiloe ka sepheo sa ho sebeletsa hamolemo sechaba sa mahlale le sa meriana ka lisebelisoa tsa boleng bo holimo tsa antibody drug conjugate (ADC) le lits'ebeletso. Ka 2013, Sorrento e ile ea fumana Concortis, ea theha k'hamphani e holimo ea ADC. Motsoako oa G-MAB™ (laeborari ea antibody e felletseng) e nang le chefo ea thepa ea Concortis, likhokahano, le mekhoa ea ho kopanya e na le monyetla oa ho hlahisa li-ADC tse etelletseng pele indastering, molokong oa 3.

Concortis hajoale e ntse e hlahloba likhetho tse fetang 20 tse fapaneng tsa ADC (pele ho kliniki) ka lits'ebetso tsa oncology le ho feta. Ka la 19 Mphalane, 2015, Sorrento e phatlalalitse ho theoa ha Levena Biopharma e le setheo se ikemetseng ho fana ka mmaraka mefuta e mengata e fapaneng ea lits'ebeletso tsa ADC ho tloha ha ho ne ho qaloa morero oa ADC ka ho etsa cGMP ea li-ADC ho isa mohatong oa I/II oa lithuto tsa bongaka. Ho fumana lintlha tse felletseng, ka kopo etela www.levenabiopharma.com

Lethathamo la lintlha tsa SmartPharm Therapeutics, Inc

SmartPharm Therapeutics, Inc. (“SmartPharm”), e leng lekala le nang le ruilweng ka botlalo la Sorrento Therapeutics, Inc. (Nasdaq: SRNE), ke k'hamphani ea nts'etsopele ea biopharmaceutical e shebaneng le liphekolo tsa lefutso tse seng tsa kokoana-hloko bakeng sa kalafo ea mafu a tebileng kapa a sa tloaelehang ka pono ea ho theha "biologics ho tsoa kahare." Hajoale SmartPharm e ntse e nts'etsapele buka e bitsoang "DNA-encoded monoclonal antibody" ho thibela ts'oaetso ea SARS-CoV-2, kokoana-hloko e bakang COVID-19 tlasa konteraka le Setsi sa Ts'ireletso ea Ts'ireletso e Phahameng ea Lefapha la Ts'ireletso la US. SmartPharm e qalile ts'ebetso ka 2018 mme e na le ntlo-kholo e Cambridge, MA, USA.

Areka Phoofolo Bophelo bo Botle

Ark Animal Health ke setsi sa letsoho se felletseng sa Sorrento. Ark e thehiloe ka 2014 ho tlisa litharollo tse ncha tsa 'maraka oa liphoofolo tse fanoeng ho tsoa mesebetsing ea lipatlisiso le nts'etsopele ea batho ea Sorrento. E ntse e hlophisoa hore e be mokhatlo o ikemetseng le o ikemetseng ka ho feletseng hang ha o fihla sethaleng sa khoebo (lihlahisoa tse loketseng ho fumana tumello ea FDA).

Lenaneo la ntshetsopele ya lead la Ark (ARK-001) ke lethal dose le le leng la resiniferatoxin (RTX) motswako o hlwekileng wa ente. ARK-001 e amohetse FDA CVM (Center for Veterinary Medicine) MUMS (tšebeliso e nyane/mefuta e menyane) bakeng sa taolo ea bohloko ba mofetše oa masapo ho lintja. Merero e meng e kenyelletsa matšoao a eketsehileng bakeng sa RTX libakeng tse kang bohloko bo sa foleng ba articular ho liphoofolo tse tsamaeang, bohloko ba neuropathic ho lipere, le idiopathic cystitis ka likatse, hammoho le ho hlahloba menyetla ea tsoelo-pele sebakeng sa mafu a tšoaetsanoang kapa phekolo ea kankere.

Bophelo bo botle ba Virex