San Diego, CA – March 3, 2014 – Sorrento Therapeutics, Inc. (NASDAQ: SRNE; Sorrento) a late-stage clinical oncology company developing new treatments for cancer and associated pain, today announced the addition of anesthesiologist and pain specialist, Mike Royal, M.D., JD and MBA. He was most recently Chief of Clinical Affairs at AcelRx.

“Mike’s expertise in drug development and pain management is exceptional and key to our success in advancing our clinical pipeline,” said Henry Ji, Ph.D., President and Chief Executive Officer of Sorrento.

Dr. Royal commented, “I am very excited to join Sorrento during this period of rapid growth and to lead the development of Sorrento’s clinical pipeline of oncologic and pain related assets.  I look forward to working with the Sorrento team to bring these groundbreaking targeted therapeutics to patients and physicians.”

Dr. Royal brings more than 20 years of drug development experience where he was a key contributor to over a dozen ANDAs, and several NDAs, most recently Zalviso™ at AcelRx and Ofirmev^® at Cadence (currently being acquired by Mallinckrodt).  He is board certified in internal medicine, pain medicine, anesthesiology with additional certification in pain management, addiction medicine, and legal medicine. He has authored or co-authored more than 170 papers and abstracts.  Previously, he was a clinical adjunct professor at the University of California San Diego and the University of Oklahoma Medial School, and a faculty member at the University of Pittsburg Medical Center.  He has also worked at Elan, Alpaharma and Solstice Neuroscience.  He graduated from the Massachusetts Institute of Technology in synthetic organic chemistry. He earned his M.D. from the Massachusetts Medical School, law degree from the University of Maryland School of Law, and MBA from TRIUM (NYU-Sern, HEC-Pairs and the London School of Economics).

About Sorrento Therapeutics, Inc.
Sorrento is an oncology company developing new treatments for cancer and associated pain. Sorrento’s most advanced asset Cynviloq, the next-generation paclitaxel, will commence its registrational trial and be developed under the abbreviated 505(b)(2) regulatory pathway. Sorrento is also developing RTX, a non-opiate TRPV1 agonist currently in a Phase 1/2 study at the National Institutes of Health to treat terminal cancer patients suffering from intractable pain. The Company has made significant advances in developing human monoclonal antibodies, complemented by a comprehensive and fully integrated ADC platform that includes proprietary conjugation chemistries, linkers, and toxic payloads. Sorrento’s strategy is to enable a multi-pronged approach to combating cancer with small molecules, therapeutic antibodies, and ADCs.

More information is available at www.sorrentotherapeutics.com.

Forward-Looking Statements
This press release contains forward-looking statements under the safe harbor provisions of Section 21E of the Private Securities Litigation Reform Act of 1995 and subject to risks and uncertainties that could cause actual results to differ materially from those projected.  Forward-looking statements include statements about the potential for the successful advancement of our clinical-stage products; the retention of key personnel; and other matters that are described in Sorrento’s Annual Report on Form 10-K for the year ended December 31, 2012, and subsequent Quarterly Reports on Form 10-Q filed with the Securities and Exchange Commission, including the risk factors set forth in those filings.  Investors are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date of this release and we undertake no obligation to update any forward-looking statement in this press release except as required by law.

Contact(s):
Mr. Amar Singh
EVP and Chief Business Officer
Sorrento Therapeutics, Inc.
asingh@sorrentotherapeutics.com
T: + 1 (858) 210-3719

Mr. Ian Stone
Account Director
Canale Communications
ian@canalecomm.com
T: + 1 (619) 849-5388

San Diego, CA – February 11, 2014 – Sorrento Therapeutics, Inc. (NASDAQ: SRNE; Sorrento), a late-stage clinical oncology company developing new treatments for cancer and associated pain, today announced that it will present results of preclinical and Phase II clinical studies of Cynviloq™ in patients with metastatic pancreatic cancer at the Beaujon International Conference: Cutting Edge in Liver and Pancreatic Tumors in Paris, France on February 13, 2014. Highlights of the findings include data on Cynviloq Phase II monotherapy and Phase I combination therapy with Gemcitabine that support similar efficacy of Cynviloq when compared to historical data for nab-paclitaxel (Abraxane^®).

The findings will be presented by Paul Bhar, vice president of Biometrics at Sorrento, during the poster session titled, “Pancreatic Tumors – Novel Treatment Options,” to be held at Pullman Montparnasse Hotel.  The presentations are “Evaluation of a Non-Biologic Nanoparticle Form of Paclitaxel in Metastatic Pancreatic Cancer,” authored by Kouros Motamed, Larn Hwang, Paul Bhar, David Nam and Vuong Trieu, and “Preclinical Evaluation of NBN-Paclitaxel against Pancreatic Xenograft Models,” authored by Vuong Trieu, Paul Bhar, Jeff Hsu, Monica Choi and Larn Hwang.

Mr. Bahr led the biostatistical team at Abraxis BioScience, Inc., and was instrumental in the approval of Abraxane^® in multiple indications.  He is now leading the biostatistical team at Sorrento and will play an important role in the preparation of the NDA filing for Cynviloq.

About Cynviloq™
Cynviloq (Genexol-PM^® or IG-001; a paclitaxel-loaded micellar diblock copolymer) is a next-generation branded paclitaxel formulation for the potential treatment of metastatic breast cancer, non-small cell lung cancer, pancreatic cancer, and other solid tumors. In July 2013, the FDA Division of Oncology Products 1 agreed that the data available are sufficient to support a 505(b)(2) pathway, using Abraxane and Taxol^® as the Reference Listed Drugs, to obtain approval. Sorrento anticipates initiating the single Bioequivalence trial required for registration, in the first quarter of 2014.

Sorrento has exclusive distribution rights to Cynviloq in North America, the 27 countries of the European Union and Australia, from Samyang Biopharmaceuticals, a South Korean corporation.

About Sorrento Therapeutics, Inc.
Sorrento is an oncology company developing new treatments for cancer and associated pain. Sorrento’s most advanced asset Cynviloq, the next-generation paclitaxel, will commence its registrational trial and be developed under the abbreviated 505(b)(2) regulatory pathway. Sorrento is also developing RTX, a non-opiate TRPV1 agonist currently in a Phase 1/2 study at the National Institutes of Health to treat terminal cancer patients suffering from intractable pain. The Company has made significant advances in developing human monoclonal antibodies, complemented by a comprehensive and fully integrated Antibody Drug Conjugate (ADC) platform that includes proprietary conjugation chemistries, linkers, and toxic payloads. Sorrento’s strategy is to enable a multi-pronged approach to combating cancer with small molecules, therapeutic antibodies, and ADCs.

More information is available at www.sorrentotherapeutics.com.

Forward-Looking Statements
This press release contains forward-looking statements under the safe harbor provisions of Section 21E of the Private Securities Litigation Reform Act of 1995 and subject to risks and uncertainties that could cause actual results to differ materially from those projected.  Forward-looking statements include statements about the potential for products to be successfully developed using proprietary technologies; the synergies and prospects for a combined enterprise going forward, including the retention of key personnel; and the clinical development and commercial potential of conjugated antibodies that may be developed based on recently acquired technologies; the potential for claims from third parties regarding the use of the ADCs and related technology that may be developed; the costs and expenses associated with additional clinical development programs from successful product development efforts, if any; and other matters that are described in Sorrento’s Annual Report on Form 10-K for the year ended December 31, 2012, and subsequent Quarterly Reports on Form 10-Q filed with the Securities and Exchange Commission, including the risk factors set forth in those filings.  Investors are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date of this release and we undertake no obligation to update any forward-looking statement in this press release except as required by law.

Genexol-PM^® is a registered trademark of Samyang Corporation; Abraxane^® is a registered trademark of Celgene, Inc; Taxol^® is a registered trademark of Bristol-Myers Squibb, Inc.

Contact(s):
Mr. Amar Singh
EVP and Chief Business Officer
Sorrento Therapeutics
asingh@sorrentotherapeutics.com
T: + 1 (858) 210-3719

Mr. Ian Stone
Account Director
Canale Communications
ian@canalecomm.com
T: + 1 (619) 849-5388

San Diego, CA – February 10, 2014 – Sorrento Therapeutics, Inc. (NASDAQ: SRNE; Sorrento), a late-stage clinical oncology company developing new treatments for cancer and associated pain, announced today the Company has obtained exclusive rights to Cynviloq™ (marketed as Genexol-PM^® in South Korea and other countries) in Australia, Canada and Mexico from Samyang Biopharmaceuticals (“Samyang”), a South Korean corporation. Sorrento already has exclusive rights from Samyang for Cynviloq in the U.S. and the 27 countries of the European Union.

“We have made significant progress carving out the clinical and regulatory path for the Cynviloq program, and we continue to build on the global commercial opportunity for this product,” said Henry Ji, Ph.D., President and Chief Executive Officer of Sorrento. “With these expanded rights, Sorrento now covers the vast majority of its targeted Cynviloq markets”.

About Cynviloq™
Cynviloq (IG-001; a paclitaxel-loaded micellar diblock copolymer) is a next-generation branded paclitaxel formulation for the potential treatment of metastatic breast cancer, non-small cell lung cancer, pancreatic cancer, and other solid tumors. In July 2013, the FDA Division of Oncology Products 1 agreed that the data available are supportive for a 505(b)(2) pathway, using Abraxane^® and Taxol^® as the Reference Listed Drugs, to pursue approval. Sorrento anticipates initiating a single Bioequivalence trial required for registration, in the first quarter of 2014.

About Sorrento Therapeutics
Sorrento is an oncology company developing new treatments for cancer and associated pain. Sorrento’s most advanced asset Cynviloq, the next-generation paclitaxel, will commence its registrational trial and be developed under the abbreviated 505(b)(2) regulatory pathway. Sorrento is also developing RTX, a non-opiate TRPV1 agonist currently in a Phase 1/2 study at the National Institutes of Health to treat terminal cancer patients suffering from intractable pain. The Company has made significant advances in developing human monoclonal antibodies, complemented by a comprehensive and fully integrated Antibody Drug Conjugate (ADC) platform that includes proprietary conjugation chemistries, linkers, and toxic payloads. Sorrento’s strategy is to enable a multi-pronged approach to combating cancer with small molecules, therapeutic antibodies, and ADCs.

More information is available at www.sorrentotherapeutics.com.

Forward-Looking Statements
This press release contains forward-looking statements under the safe harbor provisions of Section 21E of the Private Securities Litigation Reform Act of 1995 and subject to risks and uncertainties that could cause actual results to differ materially from those projected.  Forward-looking statements include statements about the potential for products to be successfully developed using proprietary technologies; the synergies and prospects for a combined enterprise going forward, including the retention of key personnel; and the clinical development and commercial potential of conjugated antibodies that may be developed based on recently acquired technologies; the potential for claims from third parties regarding the use of the ADCs and related technology that may be developed; the costs and expenses associated with additional clinical development programs from successful product development efforts, if any; and other matters that are described in Sorrento’s Annual Report on Form 10-K for the year ended December 31, 2012, and subsequent Quarterly Reports on Form 10-Q filed with the Securities and Exchange Commission, including the risk factors set forth in those filings.  Investors are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date of this release and we undertake no obligation to update any forward-looking statement in this press release except as required by law.

Genexol-PM^® is a registered trademark of Samyang Corporation; Abraxane^® is a registered trademark of Celgene, Inc; Taxol^® is a registered trademark of Bristol-Myers Squibb, Inc.

Contact(s):
Mr. Amar Singh
EVP and Chief Business Officer
Sorrento Therapeutics
asingh@sorrentotherapeutics.com
T: + 1 (858) 210-3719

Mr. Ian Stone
Account Director
Canale Communications
ian@canalecomm.com
T: + 1 (619) 849-5388

San Diego, CA – February 6, 2014 — Sorrento Therapeutics, Inc. (NASDAQ: SRNE; Sorrento), a late-stage clinical oncology company developing new treatments for cancer and associated pain, announced today that Dr. Henry Ji, President and Chief Executive Officer of Sorrento, will present at the 16^th Annual BIO CEO & Investor Conference. Hosted by the Biotechnology Industry Organization (BIO), the 16th Annual BIO CEO & Investor Conference will take place February 10 -11 at the Waldorf Astoria in New York City.

Event:    16^th Annual BIO CEO & Investor Conference
When:    Monday, February 10, 2014 at 4:30 PM EST
Where:   Duke of Windsor (4^th Floor) – Waldorf Astoria

A live webcast of the presentation can be accessed through the investor relations section of the Company’s website at www.sorrentotherapeutics.com. Following the live presentation, a replay of the webcast will be available on the Company’s website for 30 days.

About Sorrento
Sorrento is an oncology company developing new treatments for cancer and associated pain. Sorrento’s most advanced asset Cynviloq, the next-generation paclitaxel, will commence its registrational trial and be developed under the abbreviated 505(b)(2) regulatory pathway. Sorrento is also developing RTX, a non-opiate TRPV1 agonist currently in a Phase 1/2 study at the National Institutes of Health to treat terminal cancer patients suffering from intractable pain. The Company has made significant advances in developing human monoclonal antibodies, complemented by a comprehensive and fully integrated Antibody Drug Conjugate (ADC) platform that includes proprietary conjugation chemistries, linkers, and toxic payloads. Sorrento’s strategy is to enable a multi-pronged approach to combating cancer with small molecules, therapeutic antibodies, and ADCs.

Forward-Looking Statements
This press release contains forward-looking statements under the safe harbor provisions of Section 21E of the Private Securities Litigation Reform Act of 1995 and subject to risks and uncertainties that could cause actual results to differ materially from those projected.  Forward-looking statements include statements about the potential for products to be successfully developed using proprietary technologies; the synergies and prospects for a combined enterprise going forward, including the retention of key personnel; and the clinical development and commercial potential of conjugated antibodies that may be developed based on recently acquired technologies; the potential for claims from third parties regarding the use of the ADCs and related technology that may be developed; the costs and expenses associated with additional clinical development programs from successful product development efforts, if any; and other matters that are described in Sorrento’s Annual Report on Form 10-K for the year ended December 31, 2012, and subsequent Quarterly Reports on Form 10-Q filed with the Securities and Exchange Commission, including the risk factors set forth in those filings.  Investors are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date of this release and we undertake no obligation to update any forward-looking statement in this press release except as required by law.

Contact(s):
Mr. Amar Singh
EVP and Chief Business Officer
Sorrento Therapeutics, Inc.
asingh@sorrentotherapeutics.com
T: + 1 (858) 210-3719

Ian Stone
Account Director
Canale Communications
ian@canalecomm.com
T: + 1 (619) 849-5388

San Diego, CA – February 3, 2014 – Sorrento Therapeutics, Inc. (NASDAQ: SRNE; Sorrento) a late-stage clinical oncology company developing new treatments for cancer and associated pain, today announced the addition of Clinical Oncologist Daniel Levitt, M.D., Ph.D., as a member to its Board of Directors. He currently serves as Executive Vice President and Chief Medical Officer of CytRx Corporation.

“Daniel’s proven expertise overseeing the successful development of major oncology drugs will be invaluable to Sorrento as we advance our pipeline to address the unmet needs of cancer patients,” said Henry Ji, Ph.D., President and Chief Executive Officer of Sorrento.

Dr. Levitt commented, “I am excited to join Sorrento’s Board of Directors at this pivotal juncture in Sorrento’s evolution as it conducts its registrational trial with Cynviloq™. Sorrento’s lead clinical assets and its strong therapeutic antibody and ADC technologies hold excellent potential for creating groundbreaking therapies. I look forward to working with the Sorrento team to help cancer patients and their physicians.”

Dr. Levitt brings more than 28 years of senior management experience, spearheading numerous oncology drug development programs to commercialization at leading biotechnology and pharmaceutical companies, including CytRx Corporation, Cerimon Pharmaceuticals, Dynavax Technologies Corporation, Affymax, Protein Design Labs, Geron, Sandoz Pharmaceuticals, and Hoffmann-LaRoche. He graduated Magna Cum Laude and Phi Beta Kappa with a Bachelor of Arts degree from Brandeis University. He earned both his M.D. and his Ph.D. in Biology from the University of Chicago, Pritzker School of Medicine. Dr. Levitt has received 10 major research awards and authored or co-authored more than 200 papers and abstracts.

In addition, Sorrento announced that Ernst-Guenter Afting, Ph.D. has stepped down from the Board of Sorrento to focus on consulting and board activities in Europe. “We thank Dr. Afting for his many contributions to the Company,” said Henry Ji.

About Sorrento Therapeutics, Inc.
Sorrento is an oncology company developing new treatments for cancer and associated pain. Sorrento’s most advanced asset is Cynviloq, the next-generation paclitaxel, which will commence its registrational trial and be developed under the abbreviated 505(b)(2) regulatory pathway. Sorrento is also developing RTX, a non-opiate TRPV1 agonist currently in a Phase 1/2 study at the National Institutes of Health to treat terminal cancer patients suffering from intractable pain. The Company has made significant advances in developing human monoclonal antibodies, complemented by a comprehensive and fully integrated ADC platform that includes proprietary conjugation chemistries, linkers, and toxic payloads. Sorrento’s strategy is to enable a multi-pronged approach to combating cancer with small molecules, therapeutic antibodies, and ADCs.

More information is available at www.sorrentotherapeutics.com.

Forward-Looking Statements

This press release contains forward-looking statements under the safe harbor provisions of Section 21E of the Private Securities Litigation Reform Act of 1995 and subject to risks and uncertainties that could cause actual results to differ materially from those projected.  Forward-looking statements include statements about the potential for products to be successfully developed using the Concortis technologies; the synergies and prospects for a combined enterprise going forward, including the retention of key personnel; and the clinical development and commercial potential of conjugated antibodies that may be developed based on the acquired technologies; the potential for claims from third parties regarding the use of the antibody-drug conjugates and related technology that may be developed from the merger; the costs and expenses associated with the merger and additional clinical development programs from successful product development efforts; and other matters that are described in Sorrento’s Annual Report on Form 10-K for the year ended December 31, 2012, and subsequent Quarterly Reports on Form 10-Q filed with the Securities and Exchange Commission, including the risk factors set forth in those filings.  Investors are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date of this release and we undertake no obligation to update any forward-looking statement in this press release except as required by law.

Contact(s):
Mr. Amar Singh
EVP and Chief Business Officer
Sorrento Therapeutics, Inc.
asingh@sorrentotherapeutics.com
T: + 1 (858) 210-3719

Mr. Ian Stone
Account Director
Canale Communications
ian@canalecomm.com
T: + 1 (619) 849-5388

MEDIA ADVISORY

What:
Sorrento Therapeutics, Inc. [SRNE], an oncology company developing new treatments for cancer and associated pain, will visit the NASDAQ MarketSite in Times Square.

In honor of the occasion, Henry Ji, CEO will ring the Closing Bell.

Where:
NASDAQ MarketSite – 4 Times Square – 43^rd & Broadway – Broadcast Studio

When:
Friday, January 24, 2014 – 3:45 p.m. to 4:00 p.m. ET

Contact:
Amar Singh
(858) 210-3719
asingh@sorrentotherapeutics.com

NASDAQ MarketSite:
Christine Barna
(646) 441-5310
Christine.Barna@nasdaqomx.com

Feed Information:
Fiber Line (Encompass Waterfront): 4463
Gal 3C/06C 95.05 degrees West
18 mhz Lower
DL 3811 Vertical
FEC 3/4
SR 13.235
DR 18.295411
MOD 4:2:0
DVBS QPSK

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Webcast:
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To obtain a hi-resolution photograph of the Market Close, please go to http://www.nasdaq.com/reference/marketsite_events.stm and click on the market close of your choice.

About Sorrento Therapeutics, Inc. [SRNE]:
Sorrento Therapeutics is an oncology company developing new treatments for cancer and associated pain. Sorrento’s most advanced asset is Cynviloq™, the next-generation paclitaxel, which will commence its registrational trial and be developed under the abbreviated 505(b)(2) regulatory pathway. Sorrento is also developing RTX, a non-opiate TRPV1 agonist currently in a Phase 1/2 study at the National Institutes of Health to treat terminal cancer patients suffering from intractable pain. The Company has made significant advances in developing human monoclonal antibodies, complemented by a comprehensive and fully integrated antibody drug conjugate (ADC) platform that includes proprietary conjugation chemistries, linkers, and toxic payloads. Sorrento’s strategy is to enable a multi-pronged approach to combating cancer with small molecules, therapeutic antibodies, and ADCs.

About NASDAQ OMX Group:
NASDAQ OMX (NASDAQ: NDAQ) is a leading provider of trading, exchange technology, information and public company services across six continents. Through its diverse portfolio of solutions, NASDAQ OMX enables customers to plan, optimize and execute their business vision with confidence, using proven technologies that provide transparency and insight for navigating today’s global capital markets. As the creator of the world’s first electronic stock market, its technology powers more than 80 marketplaces in 50 countries, and approximately 1 in 10 of the world’s securities transactions. NASDAQ OMX is home to more than 3,300 listed companies with a market value of over $7 trillion and more than 10,000 corporate clients. To learn more, visit www.nasdaqomx.com.

San Diego, CA – January 9, 2014 – Sorrento Therapeutics, Inc. (NASDAQ: SRNE; Sorrento) a late-stage clinical oncology company developing new treatments for cancer and associated pain, today announced the addition of industry veteran William Marth, as Chairman of the Board of Directors.

Mr. Marth was the President and CEO of Teva – Americas until the end of 2012, and served as a senior advisor to Teva Pharmaceuticals until the end of 2013. During his tenure at Teva – Americas, Mr. Marth played a key role in building the organization to a $12 billion business and in the strategy behind the acquisitions of Cephalon for $6.8 billion and Barr Pharmaceuticals for $7.4 billion. Earlier in his career, he held leadership positions in sales and marketing in the Apothecon Division of Bristol-Myers Squibb. Mr. Marth was previously Chairman and is currently the President and CEO of Albany Molecular Research Inc. (AMRI), a company that provides fully integrated drug discovery, development and manufacturing services. In addition, Bill previously served as an advisor to several large equity firms providing guidance on their healthcare investments.

“We are privileged to have an accomplished and visionary industry leader with an unparalleled record of commercial success join as Chairman of our Board of Directors. Bill’s experience from building Teva – Americas into a leading specialty pharmaceutical company is an excellent fit for the strategy and vision of our Company at this stage, as the Company matures from a developer of oncology products into a commercial organization,” said Henry Ji, President and Chief Executive Officer of Sorrento. “We believe that Bill’s global operating experience in multiple therapeutic areas and strategic insights across core functional areas will be a significant asset to Sorrento as we continue to execute on our strategic plans”.

Mr. Marth commented, “I am delighted to join Sorrento’s Board of Directors and work with such a talented team. Sorrento’s lead clinical assets and its strong drug discovery platforms, hold remarkable potential for groundbreaking therapies. I am excited about Sorrento’s depth and strength in management, science and late stage assets to help cancer patients and their physicians”.

Mr. Marth received his bachelor’s degree in pharmacy from the University of Illinois, and master’s degree in business administration from the Keller Graduate School of Management, DeVry University.

In addition, Sorrento announced that David R. Webb, Ph.D. has stepped down from the Board of Sorrento to pursue other opportunities. “We would like to thank David for his many contributions to the Company,” said Henry Ji.

About Sorrento Therapeutics, Inc.
Sorrento is an oncology company developing new treatments for cancer and associated pain. Sorrento’s most advanced asset is Cynviloq™, the next-generation paclitaxel, which will commence its registrational trial and be developed under the abbreviated 505(b)(2) regulatory pathway. Sorrento is also developing RTX, a non-opiate TRPV1 agonist currently in a Phase 1/2 study at the National Institutes of Health to treat terminal cancer patients suffering from intractable pain. The Company has made significant advances in developing human monoclonal antibodies, complemented by a comprehensive and fully integrated antibody drug conjugate (ADC) platform that includes proprietary conjugation chemistries, linkers, and toxic payloads. Sorrento’s strategy is to enable a multi-pronged approach to combating cancer with small molecules, therapeutic antibodies, and ADCs.

Forward-Looking Statements


This press release contains forward-looking statements under the safe harbor provisions of Section 21E of the Private Securities Litigation Reform Act of 1995 and subject to risks and uncertainties that could cause actual results to differ materially from those projected. Forward-looking statements include statements about the potential for products to be successfully developed using the Concortis technologies; the synergies and prospects for a combined enterprise going forward, including the retention of key personnel; and the clinical development and commercial potential of conjugated antibodies that may be developed based on the acquired technologies; the potential for claims from third parties regarding the use of the antibody-drug conjugates and related technology that may be developed from the merger; the costs and expenses associated with the merger and additional clinical development programs from successful product development efforts; and other matters that are described in Sorrento’s Annual Report on Form 10-K for the year ended December 31, 2012, and subsequent Quarterly Reports on Form 10-Q filed with the Securities and Exchange Commission, including the risk factors set forth in those filings. Investors are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date of this release and we undertake no obligation to update any forward-looking statement in this press release except as required by law.

Contact(s):
Mr. Amar Singh
EVP and Chief Business Officer
Sorrento Therapeutics, Inc.
asingh@sorrentotherapeutics.com
T: + 1 (858) 210-3702

Mr. Ian Stone
Account Director
Canale Communications
ian@canalecomm.com
T: + 1 (619) 849-5388

San Diego, CA – January 8, 2014 – Sorrento Therapeutics, Inc. (NASDAQ: SRNE; Sorrento; www.sorrentotherapeutics.com), a late-stage clinical oncology company developing new treatments for cancer and associated pain, today announced the appointment of Amar Singh as Executive Vice President and Chief Business Officer. In this role, Mr. Singh will be responsible for overseeing Sorrento’s partnering activities. He brings over 25 years of experience in business and commercial development, strategic planning and operations to Sorrento.

“Amar joins us at a pivotal phase in our Company’s growth as we advance Cynviloq™ into its registrational trial and continue the development of resiniferatoxin (RTX),” said Henry Ji, Ph.D., President and CEO of Sorrento. “His successful track record of initiating and closing complex transactions, in addition to managing strategic alliances, will be particularly useful for both our clinical as well as early-stage programs.”
“Sorrento has assembled a rich and impressive product candidate portfolio that includes late-stage drug candidates in addition to a diverse antibody platform featuring PD-L1 and PD-1 targeting antibodies as well as Antibody Drug Conjugates (ADCs),” said Mr. Singh. “With these assets, Sorrento has the potential to establish several strategic partnerships on a global basis.”
Mr. Singh joins Sorrento from Synta Pharmaceuticals, where he was a Senior Vice President and Chief Business Officer. In this position, he was responsible for leading several teams, including business and commercial development, clinical operations, project management, CMC, and quality assurance. Prior to joining Synta, Mr. Singh was the Chief Operating Officer at Spectrum Pharmaceuticals, where he spearheaded numerous strategic and commercial transactions, including the in-licensing of Belinostat. Prior to this position, Mr. Singh was Vice President and Chief Commercial Officer at Novacea (now Transcept Pharmaceuticals), where he concluded a global collaboration for its lead product with Schering-Plough valued at more than $500 million. In addition, Mr. Singh led the launch of the proprietary division of American Pharmaceutical Partners – Abraxis Oncology and provided leadership in all aspects of commercial and strategic development for the company’s flagship product, Abraxane®. Before joining Abraxis, Mr. Singh held several leadership positions in the oncology franchise at Hoffmann-La Roche, where he directed the launches of several oncology and supportive care products, such as Xeloda® and Kytril®.

Mr. Singh received his master’s degree in business administration from the Stern School of Business at New York University and his bachelor’s degree from the University of North Carolina at Chapel Hill.

About Sorrento Therapeutics, Inc.
Sorrento is an oncology company developing new treatments for cancer and associated pain. Sorrento’s most advanced asset is Cynviloq™, the next-generation paclitaxel, which will commence its registrational trial and be developed under the abbreviated 505(b)(2) regulatory pathway. Sorrento is also developing RTX, a non-opiate TRPV1 agonist currently in a Phase 1/2 study at the National Institutes of Health to treat terminal cancer patients suffering from intractable pain. The company has made significant advances in developing human monoclonal antibodies, complemented by a comprehensive and fully integrated ADC platform that includes proprietary conjugation chemistries, linkers, and toxic payloads. Sorrento’s strategy is to enable a multi-pronged approach to combating cancer with small molecules, therapeutic antibodies, and ADCs.

Forward-Looking Statements
This press release contains forward-looking statements under the safe harbor provisions of Section 21E of the Private Securities Litigation Reform Act of 1995 and subject to risks and uncertainties that could cause actual results to differ materially from those projected. Forward-looking statements include statements about the potential for products to be successfully developed using the Concortis technologies; the synergies and prospects for a combined enterprise going forward, including the retention of key personnel; and the clinical development and commercial potential of conjugated antibodies that may be developed based on the acquired technologies; the potential for claims from third parties regarding the use of the antibody-drug conjugates and related technology that may be developed from the merger; the costs and expenses associated with the merger and additional clinical development programs from successful product development efforts; and other matters that are described in Sorrento’s Annual Report on Form 10-K for the year ended December 31, 2012, and subsequent Quarterly Reports on Form 10-Q filed with the Securities and Exchange Commission, including the risk factors set forth in those filings. Investors are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date of this release and we undertake no obligation to update any forward-looking statement in this press release except as required by law.

Contact(s):
Mr. George Uy
Chief Commercial Officer
Sorrento Therapeutics, Inc.
guy@sorrentotherapeutics.com
T: + 1 (858) 210-3702

Mr. Ian Stone
Account Director
Canale Communications
ian@canalecomm.com

T: + 1 (619) 849-5388

Transaction Provides Sorrento with Comprehensive Antibody Drug
Conjugate Technology Platform

San Diego, CA – December 19, 2013 — Sorrento Therapeutics, Inc. (NASDAQ: SRNE; Sorrento) announced today that it has completed its acquisition of Concortis Biosystems, Corp., providing Sorrento with a comprehensive technology platform to create a new generation of homogenous antibody drug conjugates (ADCs) with site-specific toxin conjugation and consistent drug-antibody ratios. With the close of the deal, Sorrento has issued an aggregate of 1,331,978 shares of its common stock to the Concortis shareholders. Based on the closing share price on December 18, 2013, the transaction is valued at $11.3 million.

With the acquisition, Sorrento adds Concortis’ proprietary cytotoxic payloads as well as C-lock^® and K-lock^® conjugation technologies that allow for site-specific toxin conjugation to the antibody. These new technologies may improve the overall stability and potency of the ADC. First-generation conjugation technologies lead to inconsistent drug-antibody ratios, which result in a heterogeneous mixture of ADCs. This variability has been a constraining factor in unlocking the full therapeutic potential for current-generation ADCs.

The ADC technology complements Sorrento’s existing development programs, particularly its G-MAB^® antibody library. The G-MAB library contains a vast and diverse array of fully functional monoclonal antibodies, including antibodies that hit the historically difficult to target G-protein-coupled receptors (GPCRs). In 2015, Sorrento expects to begin clinical testing of its monoclonal antibody targeting PD-L1 as well as its ADC targeting VEGFR2.

“While our near term clinical opportunity exists in a bioequivalence trial of Cynviloq™ beginning in 2014, this ADC technology acquired from Concortis will help maximize the potential of our G-MAB library and fuel our R&D pipeline over the long-term,” said Henry Ji, Ph.D., President and CEO of Sorrento. “The successes of first-generation ADCs have paved a path for new conjugation technologies. Our ownership of each of the key components of an ADC – the antibody, conjugation chemistry, linkers, and toxins – gives us a distinct and unique advantage in the field.”

About Sorrento Therapeutics, Inc.
Sorrento Therapeutics is an oncology company developing a deep pipeline of new product candidates for the treatment of cancer and associated pain. Sorrento is advancing Cynviloq, a next-generation paclitaxel, into a Phase 3 clinical trial via the abbreviated 505(b)(2) pathway. Sorrento is also developing Resiniferatoxin (RTX), a non-opiate TRPV1 agonist currently in a Phase 1/2 study at the National Institutes of Health to treat terminal cancer patients suffering from intractable pain. The company has also developed a diverse library of fully functional monoclonal antibodies, complemented by a comprehensive ADC platform comprised of wholly owned conjugation chemistry, linkers and toxic payloads. Sorrento’s multi-pronged approach to combating cancer with small molecules, antibodies, and ADCs provides optionality in addressing the complexity of cancer.

Forward-Looking Statements
This press release contains forward-looking statements under the safe harbor provisions of Section 21E of the Private Securities Litigation Reform Act of 1995 and subject to risks and uncertainties that could cause actual results to differ materially from those projected.  Forward-looking statements include statements about the potential for products to be successfully developed using the Concortis technologies; the synergies and prospects for a combined enterprise going forward, including the retention of key personnel; and the clinical development and commercial potential of conjugated antibodies that may be developed based on the acquired technologies; the potential for claims from third parties regarding the use of the antibody-drug conjugates and related technology that may be developed from the merger; the costs and expenses associated with the merger and additional clinical development programs from successful product development efforts; and other matters that are described in Sorrento’s Annual Report on Form 10-K for the year ended December 31, 2012, and subsequent Quarterly Reports on Form 10-Q filed with the Securities and Exchange Commission, including the risk factors set forth in those filings.  Investors are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date of this release and we undertake no obligation to update any forward-looking statement in this press release except as required by law.

More information is available at www.sorrentotherapeutics.com.

Contact(s):
Mr. George Uy
Chief Commercial Officer
Sorrento Therapeutics, Inc.
guy@sorrentotherapeutics.com
T: + 1 (858) 210-3702

Ian Stone
Account Director
Canale Communications
ian@canalecomm.com
T: + 1 (619) 849-5388

Deal bolsters Sorrento’s G-MAB® antibody library with Concortis Biosystems’ proprietary conjugation chemistries and toxins for powerful ADC platform

San Diego, CA – November 14, 2013 — Sorrento Therapeutics, Inc. (NASDAQ: SRNE; Sorrento) announced today the entry into a definitive  agreement to acquire San Diego-based Concortis Biosystems, Corp. in a deal that provides Sorrento with a comprehensive technology platform for generation of antibody drug conjugates (ADC).  Under the terms of the agreement dated November 11, 2013, subject to satisfaction of certain closing conditions, upon closing, Sorrento will issue an aggregate of 1,331,978 shares of its common stock to the Concortis shareholders.

This acquisition will enable Sorrento to utilize the antibodies identified from its G-MAB® library along with Concortis’ conjugation technologies and novel toxins to create a new generation of ADCs.  Concortis’ proprietary C-lock™ and K-lock™ conjugation chemistries enable site-specific conjugation of toxins to the antibody, which will produce homogenous ADCs with well-defined drug antibody ratios (DAR).  In contrast, approved ADCs are a heterogeneous mixture with different DARs.  This could potentially lead to better ADC stability and pharmacokinetics while reducing off-target effects compared to existing ADCs and therefore, improved therapeutic efficacy and treatment safety.

“This is a transformational event for Sorrento as very few companies have the breadth of capabilities covering all facets of ADC technology, including the antibodies, the conjugation chemistries, and the toxins,” said Henry Ji, Ph.D., President and CEO of Sorrento. “We are in an ideal position to become a leading player in this important and rapidly growing field. This also opens up new opportunities for strategic alliances.”

As part of the transaction, upon the closing, David (Zhenwei) Miao, PhD, Co-Founder, President and CSO of Concortis will become Sorrento’s Chief Technology Officer. Dr. Miao added, “The ADC space has become a fertile area for partnerships or acquisitions due to the recent FDA approvals of Adcetris®^[1] and Kadcyla®^[2]. We are truly excited by the therapeutic promise of combining our proprietary ADC technologies with Sorrento’s vast antibody pipeline.”

About Sorrento G-MAB®  The G-MAB® library is one of the industry’s most diverse antibody library comprised of high-quality, fully human antibodies with a diversity of more than ten trillion (>10¹⁶). Sorrento is advancing development of a number of potential drug product candidates, including antibodies against PD-L1, PD-1, VEGFR2, and chemokine receptors. The vast diversity of the G-MAB library has resulted in high success rate, even against difficult targets such as G Protein-Coupled Receptors (GPCRs).

About Sorrento Therapeutics, Inc.
Sorrento Therapeutics, Inc. is a publicly-traded, development-stage biopharmaceutical company engaged in the acquisition, discovery, development and commercialization of proprietary drug therapeutics for addressing significant unmet medical needs. Sorrento’s primary therapeutic focus is cancer.  Sorrento’s oncology pipeline includes Cynviloq™ (paclitaxel in polymeric micelle formulation) currently in registrational studies under the abbreviated 505(b)(2) pathway. Sorrento is also developing Resiniferatoxin (RTX), the most potent TRPV1 agonist known, which is in a Phase 1/2 study at the National Institutes of Health (NIH) to treat terminal cancer patients suffering from intractable pain. Sorrento’s proprietary G-MAB fully-human antibody library platform was designed to facilitate the rapid identification and isolation of highly specific antibody therapeutics. In addition to its proprietary ADCs, Sorrento is also developing Antibody formulated Drug Conjugates (AfDC) to target nanoparticles loaded with approved cancer drugs to tumors.

Forward-Looking Statements
This press release contains forward-looking statements under the safe harbor provisions of Section 21E of the Private Securities Litigation Reform Act of 1995 and subject to risks and uncertainties that could cause actual results to differ materially from those projected.  Forward-looking statements include statements about the satisfaction of the closing conditions required to complete the merger with Concortis;  the potential for products to be successfully developed using the Concortis technologies; the synergies and prospects for a combined enterprise going forward, including the retention of key personnel; and the clinical development and commercial potential of conjugated antibodies that may be developed based on the acquired technologies; the potential for claims from third parties regarding the use of the antibody-drug conjugates and related technology that may be developed from the merger; the costs and expenses associated with the merger and additional clinical development programs from successful product development efforts; and other matters that are described in Sorrento’s Annual Report on Form 10-K for the year ended December 31, 2012, and subsequent Quarterly Reports on Form 10-Q filed with the Securities and Exchange Commission, including the risk factors set forth in those filings.  Investors are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date of this release and we undertake no obligation to update any forward-looking statement in this press release except as required by law.

More information is available at www.sorrentotherapeutics.com.

Contact:
Mr. George Uy
Chief Commercial Officer
Sorrento Therapeutics, Inc.
guy@sorrentotherapeutics.com
T: + 1 (858) 210-3702

^[1] Adcetris^® is a registered trademark of Seattle Genetics.
^[2] Kadcyla^®is a registered trademark of Roche Genentech.