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« Emuva ku-Pipeline

Sisebenzisa isayensi esezingeni eliphezulu ukuze sakhe izindlela zokwelapha ezintsha ezizothuthukisa izimpilo zalabo abaphethwe umdlavuza, ubuhlungu obungalawuleki kanye ne-COVID-19.

Cancer ihlukene ngezakhi zofuzo, iyavumelana nezimo kakhulu, iyashintshashintsha njalo futhi ayibonakali emasosheni omzimba. Indlela yethu yokwelapha umdlavuza isekelwe enkolelweni yokuthi iziguli zizodinga indlela ye-multimodal, multipronged - eqondise isethi eyodwa noma ehlukahlukene yemigomo yeselula futhi ihlasele lezo ezisezindaweni eziningana - ngesikhathi esisodwa noma ngokulandelana, njalo futhi ngokungakhathali.

Indlela yethu yokulwa nomdlavuza yenziwa yenzeke ngephothifoliyo eyingqayizivele ye-immuno-oncology (“IO”), ehlanganisa uxhaxha olubanzi lwempahla emisha kanye ne-synergistic, njengomtapo wolwazi obanzi ophelele wamasosha omzimba (“G-MAB™”) ongakwazi zisetshenziswe ngokwazo noma zifakwe ezindleleni zokukhomba umdlavuza ezihlanganisa:

Lezi zimpahla ziphelezelwa idivayisi eqondisayo ye-lymphatic (Sofusa®) eklanyelwe ukuletha amasosha omzimba ohlelweni lwe-lymphatic, lapho amaseli omzimba eqeqeshelwa ukulwa nomdlavuza. 

Senze amasosha omzimba womuntu ngokumelene nezinhloso eziningi ezibalulekile ekwelapheni umdlavuza, okuhlanganisa i-PD-1, PD-L1, CD38, CD123, CD47, c-MET, VEGFR2, kanye nokunye okuhlosiwe okuningi, okusezigabeni ezihlukahlukene zokuthuthuka. Izinhlelo zethu ze-CAR-T zihlanganisa isigaba somtholampilo i-CD38 CAR T. Imithi yokwelapha ehlanganisa izindlela zokwelapha isesigabeni sokuqala sokuhlolwa kwe-myeloma eminingi, umdlavuza wamaphaphu, neminye imidlavuza yabadala kanye neyezingane.

  • I-CAR T (Chimeric Antigen Receptor – T Cells) elungisa ama-T-cell esiguli ukuze abulale isimila saso.
  • I-DAR T (Dimeric Antigen Receptor – T Cells) yokwelapha eshintsha ama-T-cell omnikeli onempilo ukuthi asebenze kunoma yisiphi isimila sanoma yisiphi isiguli, okuvumela ukwelashwa “ngaphandle kweshalofu” kwesimila sesiguli.
  • Ama-Antibody-Drug Conjugates (“ADCs”), kanye
  • Izinhlelo ze-Oncolytic Virus (Seprehvir™, Seprehvec™)

“Iphothifoliyo yethu eyingqayizivele yempahla yesikhulumi se-IO ayinakuqhathaniswa embonini. Kuhlanganisa ama-immune checkpoint inhibitors, amasosha omzimba angama-bispecific, ama-antibody-drug conjugates (ADCs) kanye ne-chimeric antigen receptor (CAR) kanye nemithi yokwelapha esekelwe kumaselula ye-dimeric antigen receptor (DAR), futhi kamuva nje sengeze amagciwane e-oncolytic (Seprehvir™, Seprehvec). ™). Impahla ngayinye ibonisa isithembiso esikhulu; sihlangene sizizwa benamandla okudlula ezinselele ezinzima kakhulu zomdlavuza”

– UDkt. Henry Ji, oyi-CEO

Ukuzibophezela kwethu ekuthuthukiseni izimpilo zeziguli ngalokho okucatshangwa ukuthi ubuhlungu obungenakunqandeka kuboniswa futhi ngomzamo wethu ongapheli wokuthuthukisa i-molecule encane ye-non-opioid engeyona i-opioid, i-Resiniferatoxin ("RTX").

I-Resiniferatoxin inamandla okushintsha ngokujulile indlela yokuphatha ubuhlungu ezinhlobonhlobo zezinkomba, ngenxa yomphumela onamandla futhi ohlala njalo ngokuphatha okukodwa kodwa nangenxa yezinzuzo zephrofayili yayo engeyona i-opioid.

I-RTX iphothula izivivinyo zangaphambi kokubalulekile ezinkomba zabantu ezifana ne-osteoarthritis kanye nokuphela kobuhlungu bomdlavuza wempilo, ngezifundo zokubhalisa ezibalulekile ezihlelelwe ukuqala ingxenye yesibili ka-2020.

I-RTX futhi isezivivinyweni ezibalulekile zokusetshenziswa ezinjeni ezihambisana nokunzima ukuphatha ubuhlungu bendololwane ye-arthritic. Njengoba izilwane ezifuywayo ziyingxenye yomndeni, indlela yethu yokuthuthukisa izixazululo ezintsha zokulawula ubuhlungu ihloselwe ukubandakanya ezinye izinhlobo esizithandayo!