I-Lymphatic Delivery System

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The Sofusa® I-Lymphatic Delivery System (S-LDS) iyindlela entsha yokwelapha eklanyelwe ukuletha imithi ejovayo ngokuqondile kuma-lymphatic kanye nama-systemic capillaries ngaphansi nje kwe-epidermis ngokusebenzisa i-microneedle yobunikazi kanye nohlelo lwe-microfluidics.

I-Sofusa Lymphatic Delivery System Uhlolojikelele. Vakashela www.sofufu.com »

I-sofusa-graphic01
ukumuncwa okuthuthukisiwe
 
Ukumuncwa Okuthuthukisiwe

Ngokungafani nemijovo yendabuko, uhlelo lwe-Sofusa ("i-soft transdermal infusion) luvumela ukumuncwa okulawulwayo kuma-capillaries amancane e-lymphatic kanye ne-systemic ngaphansi nje kwe-epidermis.

i-nano-structured-microneedles
 
I-Nanotopography (ekhuliswe kakhulu)

I-nanotopography yefilimu ezacile yobunikazi esetshenziswa kuma-microneedles iphumela ekwenyukeni okumangazayo kokumuncwa kwama-molecule amakhulu uma kuqhathaniswa nama-microneedles angavaliwe.


I-Intra-Lymphatic Targeting

Kumamodeli wangaphambi komtholampilo uma kuqhathaniswa nomjovo wendabuko, i-Sofusa ibonise ukusabela komtholampilo okuthuthukisiwe ngokukhuphuka kokugxila kwe-lymphatic kanye nokunciphisa ukuchayeka kwesistimu.1.

(1) Idatha esefayilini – Izifundo eziningi zangaphambi komtholampilo ezibandakanya i-etanercept, trastuzumab, CTLA-4, PD-1, kanye ne-PD-L1