The Sofusa® I-Lymphatic Delivery System (S-LDS) iyindlela entsha yokwelapha eklanyelwe ukuletha imithi ejovayo ngokuqondile kuma-lymphatic kanye nama-systemic capillaries ngaphansi nje kwe-epidermis ngokusebenzisa i-microneedle yobunikazi kanye nohlelo lwe-microfluidics.
I-Sofusa Lymphatic Delivery System Uhlolojikelele. Vakashela www.sofufu.com »
Ukumuncwa Okuthuthukisiwe
Ngokungafani nemijovo yendabuko, uhlelo lwe-Sofusa ("i-soft transdermal infusion) luvumela ukumuncwa okulawulwayo kuma-capillaries amancane e-lymphatic kanye ne-systemic ngaphansi nje kwe-epidermis.
I-Nanotopography (ekhuliswe kakhulu)
I-nanotopography yefilimu ezacile yobunikazi esetshenziswa kuma-microneedles iphumela ekwenyukeni okumangazayo kokumuncwa kwama-molecule amakhulu uma kuqhathaniswa nama-microneedles angavaliwe.
I-Intra-Lymphatic Targeting
Kumamodeli wangaphambi komtholampilo uma kuqhathaniswa nomjovo wendabuko, i-Sofusa ibonise ukusabela komtholampilo okuthuthukisiwe ngokukhuphuka kokugxila kwe-lymphatic kanye nokunciphisa ukuchayeka kwesistimu.1.
(1) Idatha esefayilini – Izifundo eziningi zangaphambi komtholampilo ezibandakanya i-etanercept, trastuzumab, CTLA-4, PD-1, kanye ne-PD-L1