I-Oncolytic Virus

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Amagciwane e-Oncolytic (Seprehvir™, Seprehvec™)

I-Oncolytic Immunotherapies

Izimpahla ze-oncolytic viral vector ye-Sorrento inguqulo eguquliwe ye-human herpes simplex virus (HSV-1). I-Seprehvir yakhelwe ukuthi inamandla okucekela phansi amangqamuzana e-tumor ngenkathi futhi ivuselela izimpendulo zamasosha omzimba esiguli. Njengengxenye yohlelo lwayo lokuthuthukiswa komtholampilo emhlabeni wonke, i-Seprehvir inikezwe iziguli ezingaphezu kwe-100 zabantu abadala kanye nezingane ezinhlobonhlobo zamathumba aqinile ahlanganisa i-glioblastoma, i-mesothelioma, i-melanoma, umdlavuza wekhanda nentamo, i-sarcoma yezingane kanye ne-neuroblastoma yezingane.

Inzuzo eyinhloko ye-Seprehvir, uma iqhathaniswa nezinye izindlela zokwelapha ezisekelwe ku-HSV ze-oncolytic, ukuthi inikezwe ngokuphephile ngokufakwa emithanjeni, nge-intratumor kanye nangokufakwa kwendawo yendawo ukuze kuqondiswe ngokukhethekile ukwelashwa kumdlavuza wesiguli.

Impahla ye-Seprehvec iphrojekthi yesizukulwane esizayo ehlose ukuhlinzeka ngezinketho zokwelapha ezengeziwe futhi ingakhiqiza ngokushesha inoveli ye-oncolytic immunotherapies:

  • "Kuqondiswe" ikakhulukazi ezinhlotsheni ezithile zamaseli wesimila
  • "Kuhlonywe" ngezakhi zofuzo ezengeziwe zokuthuthukisa ukubhujiswa kwamangqamuzana e-tumor
  • Okuhlukile "okuhlosiwe" okusebenzayo okuningi "okuhlosiwe" okuthuthukisiwe okubulala amaseli kanye nemisebenzi yokuvuselela amandla omzimba.