immunotherapy

« Emuva ku-Pipeline

I-G-MABTM Library

Ubuchwepheshe be-G-MAB bobunikazi be-Sorrento, obusungulwe uDkt. Ji, busekelwe ekusetshenzisweni kokulotshwa kwe-RNA ukuze kukhuliswe izizinda eziguquguqukayo ze-antibody kusuka kubanikeli abangaphezu kuka-600. 

Ukuhlaziywa okujulile kwedatha ye-DNA yokulandelana okujulile kubonise ukuthi umtapo wezincwadi we-G-MAB uqukethe ngaphezu kwama-quadrillion ayi-10 (1016) ukulandelana kwe-antibody okuhlukile. Lokhu kuyenza ibe ngomunye wemitapo yolwazi emikhulu evikela abantu ngokuphelele embonini ye-biopharmaceutical. Kuze kube manje, i-Sorrento isikhombe ngempumelelo amasosha omzimba womuntu ngokuphelele ngokumelene nezinhloso ze-oncogenic ezinethonya eliphezulu ezingaphezu kwe-100, okuhlanganisa i-PD-1, PD-L1, CD38, CD123, CD47, VEGFR2, ne-CCR2.

Izinga lokushaya lokuhlolwa eliphumelele kakhulu (okuhlosiwe okuhlosiwe okubalulekile okungu-100+ kuyahlolwa).

  • Ukuhlukahluka okuphezulu kakhulu (2 x 1016 ama-antibody ahlukene ngokulandelana)
  • Ubuchwepheshe bobunikazi (i-RNA amplification yokukhiqiza umtapo wezincwadi)

Amakhono Okukhiqiza:

  • indawo ye-cGMP
  • Gcwalisa/qeda amakhono
  • Ukusekelwa okugcwele kokuhlaziya