SOFUSA Platform Ifijiṣẹ Oògùn Lymphatic
Sofusa naa® Eto Ifijiṣẹ Lymphatic (S-LDS) jẹ ọna itọju tuntun ti a ṣe apẹrẹ lati fi awọn oogun abẹrẹ taara sinu lymphatic ati awọn capillaries eto eto ti o kan labẹ epidermis nipasẹ microneedle ohun-ini ati eto microfluidics.
Sofusa Lymphatic Ifijiṣẹ System Akopọ. Lọ www.sofusa.com
Awọn awoṣe iṣaaju-iwosan ṣe afihan awọn anfani ti o pọju ti ibi-afẹde lymphatic pẹlu awọn microneedles nano-draped ti Sofusa1
- > Ilọsiwaju 40 ni ifọkansi oogun ni awọn apa omi-ara vs awọn abẹrẹ subcutaneous (SC) tabi awọn infusions iṣan (IV)
- Ilọsiwaju tumo ilaluja pẹlu 1/10th iwọn lilo
- Ilọsiwaju ipa-egbogi tumo ati idinku metastases
Iwadii Itọju Ẹda Eniyan 1B RA lati ṣe ayẹwo ifijiṣẹ inu-lymphatic2
- Iwadi aami-ìmọ ọsẹ 12 ti n forukọsilẹ awọn alaisan pẹlu idahun ti ko pe si 50mg ni ọsẹsẹ Enbrel® awọn abẹrẹ subcutaneous (n=10)
- Awọn alaisan 3 akọkọ ti pari, 25mg awọn iwọn ọsẹ (50% ti iwọn lilo SC)
- 36%/38% idinku ninu Iṣẹ iṣe Arun (DAS28 ESR/CRP)
- 80% idinku ninu swollen isẹpo ka
- Ilọsiwaju 77% ni Iwọn Igbelewọn Agbaye ti Onisegun
Awọn iwadii POC Checkpoint eniyan ti nlọ lọwọ pẹlu Ile-iwosan Mayo
1) Walsh et al., “Nanotopography ṣe irọrun ni Ifijiṣẹ Transdermal Vivo… Awọn lẹta Nano, ACSJCA, 2015
2) Awọn abajade jẹ Apapọ ti awọn alaisan 3 akọkọ (ti o forukọsilẹ ni apakan), Ilana 1b ẹri-ti-imọ-imọ-imọ-imọ-iṣiro ṣiṣayẹwo lati ṣe ayẹwo aabo ati ipa awakọ ti Enbrel® ti a nṣakoso si awọn alaisan ti o ni arthritis Rheumatoid nipa lilo Sofusa® DoseConnct®