I-SOFUSA i-Lymphatic Drug Delivery Platform
I Sofusa® I-Lymphatic Delivery System (S-LDS) yindlela entsha yonyango eyilelwe ukuhambisa amayeza atofwayo ngokuthe ngqo kwi-lymphatic kunye ne-systemic capillaries nje ngaphantsi kwe-epidermis ngokusebenzisa i-microneedle yobunikazi kunye nenkqubo ye-microfluidics.
Inkqubo yokuhanjiswa kweSofusa Lymphatic isishwankathelo. Tyelela www.sofusa.com »
Iimodeli zangaphambi kweklinikhi zibonisa izibonelelo ezinokubakho zokujoliswa kwe-lymphatic kunye ne-Sofusa yobunini be-nano-draped microneedles1
- > Ukunyuka kwamaxesha angama-40 ekugxininiseni kweziyobisi kwii-lymph nodes vs ii-injection ezingaphantsi (SC) okanye i-intravenous (IV) infusions
- Ukuphucula ukungena kwe-tumor nge-1/10th dose
- Ukuphucula ukusebenza kakuhle kwe-anti-tumor kunye nokunciphisa i-metastases
Uphononongo lwe-RA lwe-Human Clinical Phase ukuvavanya unikezelo lwe-intra-lymphatic2
- I-12-iveki evulekileyo yokufunda ileyibhile yokubhalisa izigulane ezinempendulo engafanelekanga kwi-50mg ngeveki ye-Enbrel® ii-injection subcutaneous injections (n=10)
- Izigulane ze-3 zokuqala zigqityiwe, i-25mg iidosi zeveki (50% ye-SC dose)
- I-36% / 38% yokunciphisa uMsebenzi weSifo (DAS28 ESR / CRP)
- I-80% yokunciphisa inani lamalungu adumbileyo
- I-77% yokuphucula kwi-Global Assessment Score
Izifundo ze-POC zokuhlola uluntu ziqhuba neKliniki yaseMayo
1) UWalsh et al., "I-Nanotopography iKhokela kwi-Vivo Transdermal Delivery… Iileta zeNano, ACSJCA, 2015
I-2) Iziphumo ziyi-Avareji yezigulane zokuqala ze-3 (ezibhaliswe ngokuyinxenye), iSigaba se-1b ubungqina bombono-ufundo oluvulekileyo lweleyibhile ukuhlola ukhuseleko kunye nokusebenza komqhubi we-Enbrel® olawulwa kwizigulane ezine-Rheumatoid arthritis usebenzisa i-Sofusa® DoseConnct®.