Ukongezwa kwe-RTX

I-RTX (i-resiniferatoxin) yi-molecule ye-neural intervention ekhethekileyo ekhethiweyo kakhulu kwaye ingasetyenziselwa i-peripherally (umzekelo, i-nerve block, intra-articular) okanye phakathi (umzekelo, i-epidural), ukulawula intlungu engapheliyo kwiimeko ezininzi ezibandakanya i-arthritis kunye nomhlaza.

I-RTX inamandla okuba liyeza lokuqala kwiklasi elijongene nentlungu engapheliyo ngoku kwinoveli kunye nendlela ekhethekileyo, ngokujolisa kwiimbilini ezijongene nokuhanjiswa kweempawu zentlungu engapheliyo.

I-RTX ibophelela kakhulu kwi-TRPV1 i-receptors kunye nemikhosi evula iziteshi ze-calcium ezifumaneka kwi-terminal ye-nerve okanye i-soma ye-neuron (kuxhomekeke kwindlela yokulawula). Oku kuvelisa i-cation influx ecothayo kwaye eqhubekayo ekhokelela ngokukhawuleza ekucinyweni kweeseli ze-TRPV1-positive.

I-RTX inxibelelana ngokuthe ngqo kunye neeseli ze-nerve afferent ngaphandle kokuchaphazela iimvakalelo ezinje ngokubamba, uxinzelelo, iintlungu ezibukhali, imvakalelo yokungcangcazela okanye umsebenzi wokulungelelaniswa kwemisipha.

Ulawulo kwi-peripheral nerve end luphumela kwisiphumo esiqhubekayo sexesha lokunyanga intlungu ehambelana nayo isifo samathambo edolweni.

I-RTX inokuba luncedo kwizigulane ezine iintlungu zomhlaza ezingapheliyo, emva kwenaliti enye ye-epidural, ngokuthintela ngokusisigxina ukuhanjiswa komqondiso wentlungu ukusuka kwizicubu ze-tumor ukuya kwi-dorsal root ganglion (DRG) kwintambo yomgogodla, ngaphandle kweziphumo ebezingalindelekanga ezinxulunyaniswa needosi eziphezulu neziphindaphindiweyo ze-opioids. Ukuba i-opioids ihlala iyingxenye ye-arsenal yonyango kwezi zi gulane, i-RTX inamandla okunciphisa kakhulu inani kunye nokuphindaphinda kokusetyenziswa kwe-opioid.

I-RTX inikwe i-Orphan Drug Status yi-US Food and Drug Administration kunyango lwezifo eziphelayo, kuquka intlungu engapheliyo yomhlaza.

I-Sorrento iye yagqiba ngempumelelo iSigaba se-Ib ubungqina bekliniki yovavanyo lwengcamango kunye neZiko leSizwe lezeMpilo phantsi kweSivumelwano soPhando lweNtsebenziswano kunye noPhuhliso (i-CRADA) ebonise intlungu ephuculweyo kunye nokunciphisa ukusetyenziswa kwe-opioid emva kokulawulwa kwe-intrathecal (ngokuthe ngqo kwindawo yomgogodla).

Inkampani iqalise izifundo ezibalulekileyo kwaye ijonge ukufakwa kwe-NDA ngo-2024.