Iintsholongwane ze-Oncolytic (Seprehvir™, Seprehvec™)

Ii-asethi ze-oncolytic viral vector ye-Sorrento yinguqulelo elungisiweyo ye-herpes simplex virus ye-human herpes simplex virus (HSV-1). I-Seprehvir yenzelwe ukukwazi ukutshabalalisa ngokuthe ngqo iiseli zethumba ngelixa iphinda ikhuthaze iimpendulo zokuzikhusela kwizigulane. Njengenxalenye yenkqubo yophuhliso lwezonyango lwehlabathi, i-Seprehvir inikwe abantu abadala abangaphezu kwe-100 kunye nezigulana zabantwana kwiindidi zamathumba aqinileyo aquka i-glioblastoma, i-mesothelioma, i-melanoma, umhlaza wentloko kunye nentamo, i-sarcomas yabantwana kunye ne-neuroblastomas yabantwana.

Olona ncedo luphambili lwe-Seprehvir, xa kuthelekiswa nolunye unyango lwe-oncolytic olusekwe kwi-HSV, kukuba ilawulwa ngokukhuselekileyo emithanjeni, nge-intratumor kunye nangokufakwa kwengingqi yengingqi ukulungiselela ngokukodwa unyango lomhlaza wesigulana.

I-asethi ye-Seprehvec yiprojekthi yesizukulwana esizayo ejolise ekuboneleleni ngeendlela ezongezelelweyo zonyango kwaye inokuvelisa ngokukhawuleza i-oncolytic immunotherapies entsha:

• "Kujoliswe" ngokukodwa kwiintlobo ezithile zeeseli zethumba
• "Exhobile" ngeejene ezongezelelweyo zokwandisa ukutshatyalaliswa kweeseli zethumba
• Imisebenzi emininzi "ekujoliswe kuyo" kunye "nezixhobileyo" ezahlukeneyo ezinokubulala iiseli eziphuculweyo kunye nemisebenzi yokuvuselela umzimba.