Inclusion Criteria:

Admitted to hospital as in-patient (ward or ICU)
Respiratory distress – respiratory rate ≥ 30/minute (or PaO2:FiO2 <300) Bilateral lung infiltrates (CT or frontal X-ray) Supplemental oxygen started but NOT intubated or ventilated COVID-19 (SARS-CoV-2) antigen test positive (FDA-approved test); CDC confirmation not necessary Time from Enrollment to treatment must be less than 24 hours Age: 18-80 years Gender: any Suitability for cellular therapy: In the opinion of the Investigator or the Sponsor the patient is suitable for cellular therapy Cognitive function: Able to understand and willing to sign informed consent form or legally authorized representative or surrogate Exclusion

Exclusion Criteria:

Intubation / ventilation Current therapy is working, and patient is clinically improving Disease Conditions: Heart failure severe (NY Heart Association Classification IV); Clinical evidence of left heart failure or volume overload as a primary explanation for the bilateral pulmonary infiltrates; Any disease or condition other than current respiratory COVID-19 disease for which 6-month mortality is estimated to be greater than 50%; Moderate to severe liver failure; Severe chronic respiratory disease or the use of home oxygen use prior to this current illness; Currently receiving extracorporeal life support (ECLS/ECMO) Past Disease Conditions: Any history of malignancy within the last 2 years (except for patients in remission or cured of the malignancy); Lung transplant patient or lobectomy; Deep venous thrombosis or pulmonary embolism within past 3 months; History of splenectomy Other Experimental Conditions: Currently enrolled or treated in last 60 days in another clinical study Consent Issues: Do not resuscitate (DNR) order in place; Not willing to follow lung protective ventilation strategy, if needed Concurrent disease or circumstances that Investigator or Sponsor judges to be an unacceptable risk to patient health or a confounding variable to assessment or problem in completion of trial.