Inclusion Criteria:

Confirmed diagnosis of one of Mycosis fungoides (MF)
Stage IB to IIIB disease at screening
Received at least 1 previous line of systemic therapy for CTCL. (Participants with CD 30 positive MF must have received prior treatment with brentuximab vedotin.)
Documented disease progression during or after the last therapy.
Not previously treated with transplant and is ineligible for transplant
Willing to undergo two biopsies during the study
18 years or older at the time of signing informed consent form (ICF)
Adequate organ function
Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1
Females of childbearing potential (FCBP) must agree to use a reliable form of contraceptive for the duration of the study and for at least 120 days (4 months) following the last dose of study intervention.
Male participants must agree to use barrier contraception (i.e., condoms) for the duration of the study and for at least 120 days (4 months) following the last dose of study intervention

Exclusion

Exclusion Criteria:

Disease with extensive visceral or blood involvement.
Previously treated with an anti-PD-L1 or anti-PD-1 antibody
Any active autoimmune disease or a documented history of autoimmune disease, or history of syndrome that required systemic steroids or immunosuppressive medications, except for participants with vitiligo, hormone replacement therapy for stable thyroid diseases and Type 1 diabetes mellitus.
Prior allogeneic hematopoietic stem cell transplantation (HSCT) or solid organ transplantation.
Known seropositive for or have active infection with hepatitis C virus (HCV) or hepatitis B virus (HBV), or human immunodeficiency virus (HIV)
History of interstitial lung disease
History of severe hypersensitivity reactions to other monoclonal antibodies or known hypersensitivity to the study intervention or its excipients, indocyanine green dye or iodine.
Known current drug or alcohol abuse.
Pregnant or lactating.
Underlying medical condition resulting in abnormally slow lymphatic flow as determined by the Investigator.
Require immediate treatment for MF