Sethala sa Phaliso ea Lithethefatsi sa SOFUSA Lymphatic
The Sofusa® Lymphatic Delivery System (S-LDS) ke mokhoa o mocha oa phekolo o etselitsoeng ho fana ka meriana e nang le ente ka kotloloho ka har'a li-lymphatic le systemic capillaries ka tlas'a epidermis ka "proprietary microneedle le microfluidics system.
Sofusa Lymphatic Delivery System Overview. Etela www.sofusa.com »
Mefuta ea pele ho tleliniki e bonts'a melemo e ka bang teng ea ho shebisisa lymphatic ka Sofusa proprietary nano-draped microneedles.1
- > Keketseho ea lithethefatsi ka makhetlo a 40 ho lymph nodes vs subcutaneous injections (SC) kapa intravenous (IV) infusions.
- E ntlafalitse ho kenella ha tumor ka 1/10th dose
- E ntlafatsa katleho ea anti-tumor le ho fokotsa metastase
Human Clinical Phase 1B thuto ea RA ho lekola phano ea intra-lymphatic2
- Thuto ea libeke tse 12 e bulehileng ea label e ngolisitseng bakuli ba nang le karabelo e sa lekaneng ho 50mg beke le beke ea Enbrel® subcutaneous injections (n=10)
- Bakuli ba pele ba 3 ba qetile, litekanyetso tsa beke le beke tsa 25mg (50% ea tekanyo ea SC)
- Phokotso ea 36% / 38% ea Ts'ebetso ea Mafu (DAS28 ESR/CRP)
- Phokotso ea 80% ea palo ea manonyeletso a ruruhileng
- Ntlafatso ea 77% ho Physician Global Assessment Score
Lithuto tsa Human Checkpoint POC li ntse li tsoela pele le Mayo Clinic
1) Walsh et al., "Nanotopography e Thusa ho Phepeloa ka Vivo Transdermal… Nano Letters, ACSJCA, 2015
2) Liphetho ke Karolelano ea bakuli ba pele ba 3 (ba ngolisitsoeng ka mokhoa o itseng), Phase 1b bopaki-of-concept open label study ho hlahloba polokeho le katleho ea sefofane sa Enbrel® e fuoang bakuli ba ramatiki ea Rheumatoid ba sebelisa Sofusa® DoseConnct®.