DAR T (Dimeric Antigen Receptor-T Cell)

Sorrento e sebelisa theknoloji ea "knock-out knock-in" (KOKI) ho fetola lisele tsa T tsa mofani oa bophelo bo botle hore li li hlahise liphatsa tsa lefutso ho hlahisa "dimeric antigen receptor" sebakeng sa T-cell receptor (TCR) alpha chain constant region (TRAC). Ka tsela ena, TRAC ea ntšoa 'me antigen e oela sebakeng sa eona. 

Dimeric Antigen Receptor (DAR) e sebelisa Fab ho e-na le scFv e sebelisoang ke lisele tsa T tsa Chimeric Antigen Receptor (CAR) T. Re lumela hore DAR ena e bontšitsoe lithutong tsa preclinical ka ho khetheha, botsitso le matla.