FUJOVEE™ (Abivertinib) (Cytokine Storm – STI 5656)
FUJOVEE (Abivertinib) imorekuru diki rechitatu-chizvarwa tyrosine kinase inhibitor (TKI) iro rinonangana nemhando mbiri dzeepidermal growth factor receptor (EGFR) uye Bruton's tyrosine kinase (BTK)1.
Inhibisa muchengeti wegedhi kuchinja kweEGFR; T790M, pamwe chete neakajairika activating mutations (L858R, 19del).
Iine kushoma inhibitory chiitiko chinopesana nemhando yemusango (WT) EGFR, ichibatsira kune yayo inocherechedzwa kuchengetedza chimiro. Zvakanaka kushivirira pamuromo wedosi kusvika ku600 mg zuva nezuva.
Chikamu chechipiri cheNSCLC chidzidzo chakapera nemhedzisiro yakaburitswa muCliniki Cancer Research.2
- Pakati pe209 mhinduro inoongororwa NSCLC varwere vakatanga kuramba mutsara wekutanga TKIs:
- 93.3% (n/N: 195/209) zvidzidzo zvakawana bundu shrinkage pamaronda anovavarirwa.
- 57.4% (n/N: 120/209) zvidzidzo zvakawana mhinduro dzakanakisa dzese (yakasimbiswa + isina kusimbiswa PR).
- 52.2% (n/N: 109/209) zvidzidzo zvakawanikwa zvakasimbiswa PR.
- 28.2 mwedzi OS.
Zadzisa kiriniki yekudzidza mushumo uye gadzirira pasuru yekunanga kukurukura nzira yekutonga neFDA mu4Q22.
FDA yakapa IND mvumo muQ2 2022 yeChikamu 2 MAVERICK chidzidzo chekurapa metastatic castrate inodzivirira kenza yeprostate (mCRPC).
Iri kuedzwa zvakare seyaigona kurapwa kwecytokine dutu rakabatana neCCIDID-19 muICU varwere.
1) Epidermal Growth Factor Receptor (EGFR), Bruton Tyrosine Kinase (BTK)
2) Zvabuda paChidzidzo: https://clincancerres.aacrjournals.org/content/early/2021/11/04/1078-0432.CCR-21-2595