Lymphatic Drug Delivery

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SOFUSA Lymphatic Drug Delivery Platform

The Sofusa® Lymphatic Delivery System (S-LDS) ndi njira yatsopano yoperekera mankhwala opangira jekeseni mwachindunji m'mitsempha ya lymphatic ndi systemic capillaries pansi pa epidermis kudzera pa proprietary microneedle ndi microfluidics system.

Sofusa Lymphatic Delivery System mwachidule. Pitani www.sofusa.com »

Zitsanzo za Pre-Clinical zimawonetsa phindu lomwe lingakhalepo pakulunjika kwa ma lymphatic ndi ma microneedles a Sofusa omwe ali ndi nano-draped.1

  • Kuwonjezeka kwa 40 kwa mankhwala osokoneza bongo mu ma lymph nodes vs subcutaneous jakisoni (SC) kapena intravenous (IV) infusions
  • Kupititsa patsogolo chotupa ndi 1/10th mlingo
  • Kupititsa patsogolo mphamvu ya anti-chotupa ndikuchepetsa metastases

Kafukufuku wa Human Clinical Phase 1B RA kuti awone kubereka kwa intra-lymphatic2

  • Phunziro lotseguka la sabata la 12 lolembetsa odwala omwe alibe yankho lokwanira la 50mg sabata iliyonse ya Enbrel® subcutaneous jakisoni (n=10)
  • Odwala atatu oyamba adamaliza, 3mg Mlingo wamlungu uliwonse (25% ya mlingo wa SC)
  • Kuchepetsa 36%/38% mu Ntchito ya Matenda (DAS28 ESR/CRP)
  • 80% kuchepetsa kuchuluka kwa kutupa kwa mafupa
  • 77% kusintha kwa Physician Global Assessment Score

Maphunziro a Human Checkpoint POC akupitilira ndi Mayo Clinic

1) Walsh et al., "Nanotopography Imathandizira mu Vivo Transdermal Delivery… Nano Letters, ACSJCA, 2015
2) Zotsatira ndi Avereji ya odwala 3 oyambirira (omwe adalembetsa pang'ono), Phase 1b umboni-of-linga lotseguka label kufufuza kuti awone chitetezo ndi mphamvu yoyendetsa ndege ya Enbrel® yoperekedwa kwa odwala matenda a nyamakazi pogwiritsa ntchito Sofusa® DoseConnct®.