ululu

« Bwererani ku Pipeline

RTX

Ululu wokhudzana ndi Nyamakazi ya M'mabondo

Ululu wokhudzana ndi khansa yomaliza

RTX (resiniferatoxin) ndi mamolekyu apadera a neural intervention omwe amasankha kwambiri ndipo angagwiritsidwe ntchito mozungulira (mwachitsanzo, mitsempha ya mitsempha, intra-articular) kapena chapakati (mwachitsanzo, epidural), kuti athetse ululu wosatha m'mikhalidwe yambiri kuphatikizapo nyamakazi ndi khansa.

RTX ili ndi kuthekera kokhala mankhwala oyamba omwe akulimbana ndi zowawa zomwe sizingachitike pakali pano m'njira yatsopano komanso yapadera, poyang'ana mitsempha yomwe imayambitsa kufalikira kwa zizindikiro zowawa.

RTX imamangiriza mwamphamvu ku TRPV1 zolandilira ndikukakamiza kutsegulira njira za calcium zomwe zili kumapeto kwa mitsempha kapena soma ya neuron (malingana ndi njira yoyendetsera). Izi zimapanga kuwonjezereka kwapang'onopang'ono komanso kosasunthika komwe kumayambitsa kuchotsedwa kwa maselo abwino a TRPV1.

RTX imalumikizana mwachindunji ndi ma cell a minyewa popanda kukhudza zomverera monga kukhudza, kupanikizika, kupweteka kwapang'onopang'ono, kunjenjemera kapena kugwirizanitsa minofu.

Ulamuliro pa mapeto a mitsempha yotumphukira umapangitsa kuti pakhale nthawi yayitali yochizira ululu wokhudzana ndi nyamakazi ya bondo.

RTX imatha kuthandiza odwala omwe ali ndi kupweteka kwa khansa yomaliza, pambuyo pa jekeseni imodzi ya epidural, mwa kutsekereza kwamuyaya kufalikira kwa chizindikiro cha ululu kuchokera ku minofu ya chotupa kupita ku dorsal root ganglion (DRG) mumsana, popanda zotsatira zosafunika zomwe zimagwirizanitsidwa ndi mlingo waukulu ndi wobwerezabwereza wa opioid. Ngati ma opioid akhalabe mbali ya zida zothandizira odwalawa, RTX ili ndi mphamvu yochepetsera kwambiri kuchuluka ndi kuchuluka kwa opioid.

RTX yapatsidwa Orphan Drug Status ndi US Food and Drug Administration pochiza matenda omaliza, kuphatikiza ululu wosachiritsika wa khansa.

Sorrento yatha kukwaniritsa bwino Phase Ib umboni wachipatala wa mayesero a maganizo ndi National Institutes of Health pansi pa Cooperative Research and Development Agreement (CRADA) yomwe inasonyeza kupweteka kwabwino komanso kuchepetsa kugwiritsira ntchito opioid pambuyo poyendetsa intrathecal (molunjika ku malo a msana).

Kampaniyo idayambitsa maphunziro ofunikira ndipo ikufuna kulemba NDA mu 2024.