SOFUSA Platform nnyefe ọgwụ Lymphatic
Sofusa® Sistemụ Nnyefe Lymphatic (S-LDS) bụ usoro ọgwụgwọ ọhụrụ emebere iji wepụta ọgwụ injectable ozugbo n'ime akwara lymphatic na sistem sistem dị n'okpuru epidermis site na sistemụ microneedle na microfluidics.
Sistemụ nnyefe Lymphatic Sofusa Overview. Gaa www.sofusa.com
Modeldị tupu ụlọọgwụ na-egosipụta uru nwere ike ịdị na ebumnuche nke lymphatic na Sofusa proprietary nano-draped microneedles.1
- > Mmụba okpukpu 40 na ntinye ọgwụ n'ime oghere lymph vs subcutaneous injections (SC) ma ọ bụ intravenous (IV) infusions.
- Nbanye akpụ emelitere site na 1/10th dose
- Nrụ ọrụ mgbochi tumor yana mbelata metastases
Ọmụmụ Clinical Phase 1B RA nke mmadụ iji nyochaa nnyefe intra-lymphatic2
- Ọmụmụ ihe ọmụmụ mepere emepe nke izu 12 na-edebanye aha ndị ọrịa na-enwechaghị nzaghachi na 50mg kwa izu nke Enbrel® subcutaneous injections (n=10)
- Ndị ọrịa 3 mbụ emechara, usoro 25mg kwa izu (50% nke SC dose)
- Mbelata 36%/38% na Ọrụ Ọrịa (DAS28 ESR/CRP)
- Mbelata 80% na nkwonkwo fụrụ akpụ ọnụ
- Ọganihu 77% na akara nyocha zuru ụwa ọnụ nke dibịa
Ọmụmụ POC Checkpoint mmadụ na-aga n'ihu na ụlọ ọgwụ Mayo
1) Walsh et al., “Nanotopography na-enyere aka na nnyefe Vivo Transdermal… Akwụkwọ ozi Nano, ACSJCA, 2015
2) Nsonaazụ bụ nkezi nke ndị ọrịa 3 mbụ (edenye aha ya n'otu akụkụ), ọmụmụ akara ngosi nke oge 1b iji chọpụta nchekwa na arụmọrụ pilot nke Enbrel® na-enye ndị ọrịa nwere ọrịa ogbu na nkwonkwo site na iji Sofusa® DoseConnct®.