Rtx

RTX (resiniferatoxin) bụ mkpụrụ ndụ ntinye aka na akwara pụrụ iche nke na-ahọrọ nke ukwuu ma nwee ike itinye ya n'akụkụ (dịka ọmụmaatụ, ngọngọ akwara, intra-articular) ma ọ bụ etiti (dịka ọmụmaatụ, epidural), iji chịkwaa mgbu na-adịghị ala ala n'ọtụtụ ọnọdụ gụnyere ọrịa ogbu na nkwonkwo na ọrịa kansa.

RTX nwere ike ịbụ ọgwụ ọgwụ nke mbụ na-agwa mgbu mgbu na-adịghị agwụ agwụ ugbu a n'ụzọ ọhụrụ na nke pụrụ iche, site n'ịtụkwasị akwara ndị na-ahụ maka mgbasa ozi mgbu na-adịghị ala ala.

RTX na-ejikọta ya na ndị na-anabata TRPV1 na ndị agha na-emeghe ọwa calcium dị na njedebe njedebe nke akwara ma ọ bụ soma nke neuron (dabere na ụzọ nchịkwa). Nke a n'aka nke ya na-emepụta nbata cation dị nwayọọ na nke na-adịgide adịgide nke na-eduga ngwa ngwa na ihichapụ sel TRPV1 dị mma.

RTX na sel akwara afferent na-emekọrịta ihe ozugbo na-enweghị emetụta mmetụta dị ka mmetụ, nrụgide, nnukwu mgbu mgbu, mmetụta ịma jijiji ma ọ bụ ọrụ nhazi ahụ.

Nlekọta na njedebe akwara dị n'akụkụ na-ebute mmetụta na-adịgide adịgide maka ọgwụgwọ mgbu metụtara ọrịa ogbu na nkwonkwo nke ikpere.

RTX nwere ike inyere ndị ọrịa aka njedebe ọrịa cancer, mgbe otu ogwu ogbugba nke epidural gasịrị, site n'igbochi mgbaàmà mgbu site na anụ ahụ tumor gaa na dorsal root ganglion (DRG) na ọkpụkpụ azụ, na-enweghị mmetụta ndị na-adịghị mma na-ejikọta ya na nnukwu doses nke opioids ugboro ugboro. Ọ bụrụ na opioids anọgide na-abụ akụkụ nke ngwa agha ọgwụgwọ maka ndị ọrịa a, RTX nwere ike ibelata oke na ugboro ole a na-eji opioid eme ihe.

Ụlọ ọrụ nchịkwa nri na ọgwụ ọjọọ nke United States nyere RTX ohere maka ọgwụgwọ nke ọrịa ndị na-agwụ agwụ, gụnyere mgbu cancer na-adịghị agwụ agwụ.

Sorrento emechaala ihe ngosi ahụike nke Phase Ib dị mma nke nnwale echiche na National Institutes of Health n'okpuru nkwekọrịta nyocha na mmepe mmepe (CRADA) nke gosipụtara ihe mgbu ka mma ma belata oriri opioid mgbe nchịkwa intrathecal (kpọmkwem n'ime oghere azụ azụ).

Companylọ ọrụ ahụ ebidola ọmụmụ ihe dị mkpa ma na-achọ ntinye akwụkwọ NDA na 2024.