OVYDSO STI-1558

"Laghachi na Pipeline

OVYDSO STI-1558

Ezubere iche maka nje bụ isi protease (Mpro): na-akwụsịtụ mmegharị nje virus

Jeong, GU, et al. (2020). "Usoro ọgwụgwọ megide COVID-19 na njiri mara nke SARS-CoV-2: Nlebanya." Oke na Microbiology 11(1723).

Emebere STI-1558 na ihe ndị a:

  • STI-1558 bụ prodrug, na ụdị ya na-arụ ọrụ AC1115 jikọtara na Cys-145 nke catalytic ngalaba nke M.pro , nke echekwara 100% na ụdị SARS-CoV-2 niile wee nweta ọrụ mgbochi SARS-CoV-2 sara mbara, gụnyere megide ụdị SARS-CoV-2 mbụ yana yana ụdị nchegbu kachasị (VOCs) , dị ka Delta na Omicron.
  • STI-1558 bụ nwekwara Cathepsin L inhibitor, nke nwere ike igbochi ntinye nje virus dị irè banye n'ime sel ndị ọbịa na-enweghị ngwangwa mmụgharị nje.
  • Oral bioavailability ruo 76% site na nnabata ngwa ngwa na mkpughe ọgwụ na plasma na-enye ohere ọgwụgwọ mbụ nke COVID n'ụlọ site na nchịkwa ọnụ.
  • Zere iji ihe mgbochi CYP34A nwere ike (dịka ọmụmaatụ, ritonavir) dị ka onye na-agba ume iji welie mkpughe plasma. na-enye ohere maka ọgwụgwọ kwụ ọtọ na obere ihe ize ndụ maka mmekọrịta ọgwụ.
  • A ngwaahịa ọgwụ site na nhazi siri ike, nkwụsi ike na imepụta ihe ọgwụ buru ibu na ọnụ ahịa a na-achịkwa na-enye ohere ịnweta na ngwa zuru ụwa ọnụ.