Lymphatic Drug Delivery

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SOFUSA Lymphatic Drug Delivery Platform

Lub Sofusa® Lymphatic Delivery System (S-LDS) yog ib txoj hauv kev tshiab ntawm kev kho mob tsim los xa cov tshuaj txhaj ncaj qha mus rau hauv cov kab mob lymphatic thiab cov kab mob capillaries nyob rau hauv qab cov epidermis ntawm ib tug proprietary microneedle thiab microfluidics system.

Sofusa Lymphatic Delivery System Txheej txheem cej luam. Mus xyuas www.sofusa.com »

Cov qauv ua ntej-Clinical qhia pom cov txiaj ntsig zoo ntawm lub hom phiaj lymphatic nrog Sofusa proprietary nano-draped microneedles1

  • > 40-fold nce nyob rau hauv cov tshuaj concentration nyob rau hauv cov qog nqaij hlav vs subcutaneous txhaj (SC) los yog intravenous (IV) infusions
  • Txhim kho qog nkag nrog 1/10th koob tshuaj
  • Txhim kho kev tiv thaiv qog nqaij hlav thiab txo cov metastases

Human Clinical Phase 1B RA txoj kev tshawb fawb los soj ntsuam kev xa tawm hauv lymphatic2

  • 12-lub lim tiam qhib daim ntawv sau npe kawm rau cov neeg mob uas tsis txaus cov lus teb rau 50mg txhua lub lim tiam Enbrel® subcutaneous txhaj (n = 10)
  • Thawj 3 tus neeg mob ua tiav, 25mg koob tshuaj txhua lub lim tiam (50% ntawm SC koob)
  • 36% / 38% txo qis hauv Kab Mob Kev Ua Haujlwm (DAS28 ESR / CRP)
  • 80% txo cov pob qij txha o suav
  • 77% kev txhim kho hauv Tus Kws Kho Mob Ntiaj Teb Kev Ntsuas Score

Human Checkpoint POC kev kawm txuas ntxiv nrog Mayo Clinic

1) Walsh et al., “Nanotopography Facilitates hauv Vivo Transdermal Delivery… Nano Letters, ACSJCA, 2015
2) Cov txiaj ntsig yog Qhov Nruab Nrab ntawm thawj 3 tus neeg mob (ib nrab rau npe), Theem 1b pov thawj-ntawm-lub tswv yim qhib daim ntawv tshawb fawb los ntsuas kev nyab xeeb thiab kev ua haujlwm ntawm Enbrel® muab rau cov neeg mob Rheumatoid mob caj dab siv Sofusa® DoseConnct®