CAR T / DAR T

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CAR T (Chimeric Antigen Receptor-T Cell) 

Sorrento's cellular therapy program tsom rau Chimeric Antigen Receptor-T Cell (CAR T) rau kev siv cov tshuaj tiv thaiv kab mob los kho cov qog nqaij hlav thiab cov kua dej. 

CAR T program muaj CD38, CEA thiab CD123.

Sorrento's CD38 CAR T lub hom phiaj siab qhia CD38 cov hlwb zoo, uas yuav txwv tsis pub muaj kev phom sij rau ntawm lub hom phiaj / tawm ntawm qog.

Lub tuam txhab CD38 CAR T tus neeg sib tw tam sim no tau raug tshuaj xyuas hauv ntau yam myeloma (MM). Qhov kev zov me nyuam tau ua tiav qhov ua tau zoo ntawm cov tshuaj tiv thaiv qog noj ntshav hauv cov qauv tsiaj thiab tam sim no nyob rau theem 1 sim hauv RRMM. Tsis tas li ntawd, Sorrento tau tshaj tawm cov ntaub ntawv los ntawm Phase I sim ntawm carcinoembryonic antigen (CEA) qhia CAR T program.

Lub tuam txhab tab tom ntsuam xyuas CD123 CAR T nyob rau hauv mob myeloid leukemia (AML).

DAR T (Dimeric Antigen Receptor-T Cell)

Sorrento siv lub tswv yim knock-out knock-in (KOKI) thev naus laus zis los hloov kho cov neeg noj qab haus huv ib txwm muab los ntawm T hlwb los tsim cov noob caj noob ces kom nthuav tawm cov dimeric antigen receptor rau hauv T-cell receptor (TCR) alpha saw tas li (TRAC). Hauv qhov no, TRAC tau khob tawm thiab cov tshuaj tiv thaiv tau khob rau hauv nws qhov chaw. 

Lub Dimeric Antigen Receptor (DAR) siv Fab Kis los ntawm scFv siv los ntawm Chimeric Antigen Receptor (CAR) T cells. Peb ntseeg tias qhov DAR no tau tshwm sim nyob rau hauv kev tshawb fawb preclinical ntau dua qhov tshwj xeeb, ruaj khov thiab muaj zog.

Chimeric Antigen Receptors (CARs)

CAR T Cell Technology tam sim no

Tom ntej-Gen Dimeric Antigen Receptor (DAR) Technology

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