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RTX

ʻO ka ʻeha pili me ka Arthritis of the Knee

ʻO ka ʻeha pili me ka maʻi maʻi maʻi

ʻO ka RTX (resiniferatoxin) kahi molekele neural intervention kū hoʻokahi i koho nui ʻia a hiki ke hoʻohana ʻia i peripherally (e laʻa, nerve block, intra-articular) a i ʻole ma waena (eg, epidural), e hoʻomalu i ka ʻeha mau ma waena o nā maʻi he nui e like me ka arthritis a me ka maʻi kanesa.

Hiki i ka RTX ke lilo i lāʻau lapaʻau mua i ka papa e kamaʻilio nei i ka ʻeha i hiki ke hoʻopaʻa ʻia i kēia manawa ma ke ʻano moʻolelo a me ke ʻano kūʻokoʻa, ma ka huli ʻana i nā aʻalolo e pili ana i ka hoʻouna ʻana i nā hōʻailona ʻeha.

Hoʻopaʻa ikaika ʻo RTX i nā mea loaʻa TRPV1 a hoʻoikaika i nā kahawai calcium e wehe ʻia i ka hopena o ke aʻalolo a i ʻole ka soma o ka neuron (e pili ana i ke ala o ka hoʻokele). Hoʻopuka kēia i ka cation influx lohi a paʻa e alakaʻi wikiwiki i ka holoi ʻana i nā cell TRPV1-positive.

Hoʻopili pololei ʻo RTX me nā pūnana nerve afferent me ka ʻole o ka hoʻopili ʻana i nā manaʻo e like me ka hoʻopā ʻana, ke kaomi ʻana, ka ʻeha prickling acute, ka haʻalulu a i ʻole ka hana hoʻonohonoho ʻana i ka ʻiʻo.

ʻO ka hoʻoponopono ʻana i ka hopena o ke aʻalolo peripheral e loaʻa i kahi hopena kino e mālama ai i ka ʻeha e pili ana ʻthritishā o ke kuli.

Hiki i ka RTX ke kōkua i nā maʻi me ʻeha maʻi ʻaʻai hope, ma hope o ka epidural hoʻokahi, ma ke kāohi mau ʻana i ka hoʻouna ʻana i ka hōʻailona ʻeha mai ka ʻiʻo tumo a i ka dorsal root ganglion (DRG) i loko o ke kuamoʻo, me ka ʻole o nā hopena i makemake ʻole ʻia e pili ana i nā kiʻekiʻe a me ka pinepine o ka opioids. Inā noho ka opioids i ʻāpana o ka lāʻau lapaʻau no kēia mau maʻi, hiki i ka RTX ke hōʻemi nui i ka nui a me ka pinepine o ka hoʻohana ʻana i ka opioid.

Ua hāʻawi ʻia ʻo RTX i ka Orphan Drug Status e ka US Food and Drug Administration no ka mālama ʻana i nā maʻi hope loa, me ka ʻeha maʻi maʻi intractable.

Ua hoʻopau maikaʻi ʻo Sorrento i kahi hōʻoia hōʻoia maikaʻi o Phase Ib o ka hoʻāʻo ʻana i ka manaʻo me ka National Institutes of Health ma lalo o kahi Cooperative Research and Development Agreement (CRADA) i hōʻike i ka maikaʻi o ka ʻeha a me ka hōʻemi ʻana i ka ʻai opioid ma hope o ka hoʻokele intrathecal (pololei i loko o ka ākea spinal cord).

Ua hoʻomaka ka hui i nā haʻawina pivotal a ke manaʻo nei i kahi faila NDA ma 2024.