Dandalin Isar da Magungunan Lymphatic SOFUSA
The Sofusa® Tsarin Isar da Lymphatic (S-LDS) sabuwar hanyar jiyya ce da aka ƙera don isar da magungunan allura kai tsaye zuwa cikin ƙwayoyin lymphatic da na tsarin da ke ƙarƙashin epidermis ta hanyar microneedle na mallakar mallaka da tsarin microfluidics.
Tsarin Bayarwa Lymphatic Sofusa Overview. Ziyarci www.sofusa.com
Samfuran Pre-Clinical suna nuna yuwuwar fa'idodin niyya na lymphatic tare da Sofusa nano-draped microneedles1
- > karuwa sau 40 a cikin ƙwayar ƙwayoyi a cikin ƙwayoyin lymph vs injections subcutaneous (SC) ko intravenous (IV) infusions
- Ingantacciyar shigar ƙari tare da 1/10th kashi
- Ingantacciyar ingantaccen maganin ƙwayar cuta da rage metastases
Nazarin Clinical Phase 1B RA don tantance isar da intra-lymphatic2
- Binciken buɗaɗɗen lakabi na mako 12 yana yin rijistar marasa lafiya tare da ƙarancin amsa ga 50mg na mako-mako na allurar subcutaneous Enbrel® (n=10)
- Na farko marasa lafiya 3 sun kammala, 25mg na mako-mako (50% na kashi SC)
- Rage 36%/38% a Ayyukan Cuta (DAS28 ESR/CRP)
- 80% raguwa a cikin kumburin haɗin gwiwa ƙidaya
- 77% haɓaka a Makin Ƙididdiga na Duniya na Likita
Binciken POC na ɗan adam yana gudana tare da Mayo Clinic
1) Walsh et al., "Nanotopography Yana Sauƙaƙawa a cikin Isar da Fassarar Vivo… Nano Haruffa, ACSJCA, 2015
2) Sakamako shine Matsakaicin marasa lafiya na 3 na farko (an yi rajista a wani yanki), 1b hujja-na-ra'ayi nazarin lakabin buɗe ido don tantance aminci da ingancin matukin jirgi na Enbrel® da aka gudanar ga marasa lafiya da cututtukan cututtukan Rheumatoid ta amfani da Sofusa® DoseConnct®