Farashin RTX
RTX (resiniferatoxin) wani ƙwayar ƙwayar cuta ce ta musamman wacce ke da zaɓi sosai kuma ana iya amfani da ita ta gefe (misali, toshe jijiya, intra-articular) ko ta tsakiya (misali, epidural), don sarrafa ciwo na yau da kullun a cikin yanayi da yawa ciki har da arthritis da kansa.
RTX yana da yuwuwar zama maganin miyagun ƙwayoyi na farko a halin yanzu wanda ba zai iya jurewa ba a cikin wani labari kuma na musamman, ta hanyar ƙaddamar da jijiyoyi da ke da alhakin watsa siginar raɗaɗi mai lalacewa.
RTX yana ɗaure da ƙarfi ga masu karɓar TRPV1 kuma sojojin buɗe tashoshin calcium da ke cikin ƙarshen ƙarshen jijiya ko somawar neuron (dangane da hanyar gudanarwa). Wannan kuma yana haifar da jinkirin kuma ci gaba da kwararar cation wanda ke haifar da sauri zuwa ga gogewar TRPV1-tabbataccen sel.
RTX yana hulɗa kai tsaye tare da ƙwayoyin jijiyoyi masu banƙyama ba tare da tasiri ba kamar tabawa, matsa lamba, zafi mai tsanani, jijjiga ko aikin daidaitawar tsoka.
Gudanarwa a ƙarshen jijiya na gefe yana haifar da sakamako mai dorewa na ɗan lokaci don magance ciwon da ke hade da amosanin gabbai na gwiwa.
RTX na iya yuwuwar taimakawa marasa lafiya da ciwon daji na ƙarshe, bayan allurar epidural guda ɗaya, ta hanyar toshe siginar siginar har abada daga ƙwayar ƙwayar cuta zuwa ganglion ganglion na dorsal (DRG) a cikin kashin baya, ba tare da lahani mara kyau ba wanda ke hade da haɓaka da maimaita yawan opioids. Idan opioids sun kasance wani ɓangare na arsenal na warkewa ga waɗannan marasa lafiya, RTX yana da yuwuwar rage yawan adadin da yawan amfani da opioid.
Hukumar Abinci da Magunguna ta Amurka ta ba RTX Matsayin Marayu don maganin cututtukan ƙarshen zamani, gami da ciwon daji mai saurin jurewa.
Sorrento ya sami nasarar kammala tabbataccen shaida na asibiti na Phase Ib na gwajin ra'ayi tare da Cibiyoyin Kiwon Lafiya na Kasa a ƙarƙashin Yarjejeniyar Bincike da Ci Gaban Haɗin gwiwa (CRADA) wanda ya nuna ingantaccen ciwo da rage yawan amfani da opioid bayan gudanarwar intrathecal (kai tsaye a cikin sararin kashin baya).
Kamfanin ya fara karatu mai mahimmanci kuma yana neman yin rajistar NDA a cikin 2024.