Security holders of Sorrento Therapeutics, Inc. wishing to communicate with Sorrento’s Board of Directors (the “Board”) or an individual director may send a written communication to the Board or such director c/o Sorrento Therapeutics, Inc., 6042 Cornerstone Court West, Suite B, San Diego, CA 92121, Attn: Corporate Secretary.  Communications also may be sent to the Corporate Secretary by email at HJi@sorrentotherapeutics.com.

Each communication must set forth the name and address of the Sorrento security holder(s) on whose behalf the communication is sent and the number of Sorrento shares that are beneficially owned by such security holder(s) as of the date of the communication.  Each communication will be screened by Sorrento’s Corporate Secretary to determine whether it is appropriate for presentation to the Board or such director.  Examples of inappropriate communications include junk mail, spam, mass mailings, product complaints, product inquiries, new product suggestions, resumes, job inquiries, surveys, business solicitations and advertisements, as well as unduly hostile, threatening, illegal, unsuitable, frivolous, patently offensive or otherwise inappropriate material.

Communications determined by Corporate Secretary to be appropriate for presentation to the Board or such director will be submitted to the Board or such director on a periodic basis.  Any communications that concern questionable accounting or auditing matters involving Sorrento will be handled in accordance with the terms of Sorrento’s Code of Business Conduct and Ethics and Sorrento’s Open Door Policy for Reporting Complaints Regarding Accounting, Auditing and Other Matters.

This Process for Security Holders Communications with the Board will be posted on Sorrento’s website at www.sorrentotherapeutics.com and provided to any security holder of the Company who requests a copy by contacting the Corporate Secretary, Sorrento Therapeutics, Inc., 6042 Cornerstone Court West, Suite B, San Diego, CA 92121; (858) 210-3700.